Severe acute pancreatitis (SAP) has a complex course and a worse prognosis. Immune response imbalance is an important cause of severe pancreatitis or even death in patients. Immunomodulation therapy can regulate the imbalance of inflammatory response, alleviate SAP-related organ damage and improve the prognosis of patients. There are some problems in early immune regulation measures, such as single target and simple way. In recent years, new treatment methods, such as regulating the maturation and apoptosis of immune cells, the application of mesenchymal stem cells (MSCs) and multifactor combination therapy, have provided new ideas and hope for the future treatment of SAP. This article reviews the development of SAP immunoregulation and its recent progress.

中文翻译：

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重症急性胰腺炎免疫调节治疗的进展。

重症急性胰腺炎（SAP）病程复杂，预后较差。免疫反应失衡是严重胰腺炎甚至患者死亡的重要原因。免疫调节疗法可以调节炎症反应的失衡，减轻SAP相关器官损伤，改善患者的预后。早期免疫调节措施存在一些问题，如单一靶点和简单方法。近年来，调节免疫细胞的成熟和凋亡，间充质干细胞（MSCs）的应用和多因素联合疗法等新的治疗方法为SAP的未来治疗提供了新的思路和希望。本文回顾了SAP免疫调节的发展及其最新进展。