Noble metal nanomaterials have been studied by many researchers for their ultra-small size, excellent photophysical properties and good biocompatibility. Metal nanoclusters are a kind of nanoscale ultrafine particle, which have completely different properties from macroscopic metals. In the visible region, they do not usually show the characteristic surface plasmon resonance absorption but instead show fluorescence in the visible to near infrared region. In particular, the noble metallic (Au, Ag, Cu, etc) nanoclusters (NMNCs) have broad application prospects in the field of biomedicine as probes for fluorescence sensing. Their strong photoluminescence, living cell compatibility, and easy availability make up for the shortcomings of traditional fluorescent probes such as organic fluorescent dyes, fluorescent proteins, and fluorescent quantum dots. In this review, we summarize the synthetic method and application of metal nanoclusters as fluorescent probes in bio-sensing and imaging, especially in the early diagnosis of cancer cells.

中文翻译：

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金属纳米团簇的合成及其在生物传感和成像中的应用。

许多研究人员已经研究了贵金属纳米材料的超小尺寸，优异的光物理性质和良好的生物相容性。金属纳米团簇是一种纳米级超细颗粒，其性质与宏观金属完全不同。在可见光区域，它们通常不显示特征性的表面等离子体共振吸收，而是在可见光至近红外区域显示荧光。尤其是，贵金属（金，银，铜等）纳米团簇（NMNC）在生物医学领域作为荧光传感探针具有广阔的应用前景。它们强大的光致发光，与活细胞的相容性以及易获得性弥补了传统荧光探针（例如有机荧光染料，荧光蛋白和荧光量子点）的缺点。