BACKGROUND AND OBJECTIVE Plasma homocysteine (Hcy) levels have been investigated among patients with multiple sclerosis (MS). However, the changes in Hcy levels and the association between Hcy levels and inflammatory/immune/cerebrospinal fluid (CSF) parameters in neuromyelitis optica spectrum disorder (NMOSD) patients have not been investigated yet. METHODS Case data were collected from 97 acute-phase NMOSD patients and 39 stable-phase NMOSD patients. Patients in the acute phase were divided into 2 groups based on the EDSS score with cutoff equal to 4. Hcy levels, immunoglobulins (Ig) A, G, and M, complement 3 and 4, CH50, C-reactive protein, erythrocyte sedimentation rate (ESR), and CSF examination including white blood cells and total protein were determined. RESULTS No significant differences in Hcy levels are observed between acute-phase and stable-phase NMOSD patients. Hcy and ESR levels were significantly higher in acute-phase NMOSD patients with EDSS score ≥4. Besides, EDSS is positively correlated with Hcy level, ESR, 1/aquaporin-4 titer and Hcy level is negatively correlated with IgM in acute-phase NMOSD patients. CONCLUSION Elevated plasma Hcy has the potential to affect the pathogenesis or progression of NMOSD.

中文翻译：

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血浆同型半胱氨酸水平与神经脊髓炎性视神经频谱疾病的扩大的残疾状态量表相关。

背景和目的已研究了多发性硬化症（MS）患者的血浆高半胱氨酸（Hcy）水平。但是，尚未研究视神经脊髓炎光谱症（NMOSD）患者的Hcy水平变化以及Hcy水平与炎症/免疫/脑脊液（CSF）参数之间的关联。方法收集97例急性期NMOSD患者和39例稳定期NMOSD患者的病例数据。急性期患者根据EDSS评分分为2组，临界值等于4。Hcy水平，免疫球蛋白（Ig）A，G和M，补体3和4，CH50，C反应蛋白，红细胞沉降率（ESR）和CSF检查，包括白细胞和总蛋白。结果急性期和稳定期NMOSD患者之间的Hcy水平没有显着差异。EDSS评分≥4的急性期NMOSD患者的Hcy和ESR水平显着升高。此外，急性期NMOSD患者中EDSS与Hcy水平呈正相关，ESR，1 / aquaporin-4滴度与IgM呈负相关。结论血浆Hcy升高有可能影响NMOSD的发病或进展。