N6-methyladenosine (m⁶A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m⁶A patterns across cell lines. Here we collected all available MeRIP-Seq and m⁶A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m⁶A peaks dependent on 23 human and eight mouse cell lines respectively. Those m⁶A peaks were further classified into mRNA and lncRNA groups. To better understand the potential function of m⁶A, we then mapped m⁶A peaks in different subcellular components and gene regions. Among those human m⁶A modification, 190,050 and 150,900 peaks were identified in cancer and non-cancer cells, respectively. Finally, all results were integrated and imported into a visualized cell-dependent m⁶A database CVm6A. We believe the specificity of CVm6A could significantly contribute to the research for the function and regulation of cell-dependent m⁶A modification in disease and development.

中文翻译：

---

CVm6A：细胞系中 m⁶As 的可视化和探索数据库。

N6-甲基腺苷 (m⁶A) 已在各种生物过程中得到鉴定，并在各种细胞中发挥重要的调节功能。然而，仍然没有可视化数据库来探索跨细胞系的全局 m⁶A 模式。在这里，我们从公共数据库中收集了所有可用的 MeRIP-Seq 和 m⁶A-CLIP-Seq 数据集，并确定了 340,950 和 179,201 m⁶A 峰分别依赖于 23 个人和 8 个小鼠细胞系。那些 m⁶A 峰进一步分为 mRNA 和 lncRNA 组。为了更好地理解 m⁶A 的潜在功能，我们随后绘制了不同亚细胞成分和基因区域中的 m⁶A 峰。在这些人类 m⁶A 修饰中，分别在癌细胞和非癌细胞中鉴定了 190,050 和 150,900 个峰。最后，所有结果都被整合并导入到一个可视化的细胞依赖性 m⁶A 数据库 CVm6A 中。我们相信 CVm6A 的特异性可以显着促进疾病和发展中细胞依赖性 m⁶A 修饰的功能和调节的研究。