Introduction: When a drug hypersensitivity reaction is proven, desensitization protocols allow the reintroduction of the molecule in patients for whom such therapy is essential. Through drug desensitization (DDS), a temporary immune tolerance is maintained for the single course of a specific therapy. In pediatrics, indications for such a procedure include children with chronic diseases, severe infectious diseases and/or malignancies, who have a proven drug hypersensitivity.Areas covered: We ran a search on PubMed and Web of Science for papers on DDS and on DDS in children. Most protocols and recommendations on DDS focus on adults and have been adapted for children. The best candidates for desensitization are children with a history of immediate, IgE-mediated drug allergy, but this therapy may be applied also in nonallergic hypersensitivities and in non-immediate reactions. Most protocols in literature focus on antibiotics, especially beta-lactams, on chemotherapeutic agents, and on monoclonal antibodies.Expert opinion: Pediatric allergists should cooperate with specialists in infectious diseases and onco-hematology to provide DDS to children in need. Standardized protocols and international guidelines are still needed to optimize such treatment and to implement it in clinical daily practice.

中文翻译：

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儿童药物过敏脱敏方案。

介绍：当药物超敏反应被证实时，脱敏方案允许在需要这种治疗的患者中重新引入该分子。通过药物脱敏 (DDS)，在特定治疗的单个疗程中保持暂时的免疫耐受。在儿科中，这种手术的适应症包括患有慢性病、严重传染病和/或恶性肿瘤的儿童，他们已被证明对药物过敏。涵盖的领域：我们在 PubMed 和 Web of Science 上搜索了关于 DDS 和 DDS 的论文孩子们。大多数关于 DDS 的协议和建议侧重于成人，并已针对儿童进行了调整。脱敏的最佳候选者是有直接、IgE 介导的药物过敏史的儿童，但这种疗法也可用于非过敏性超敏反应和非即时反应。文献中的大多数方案都侧重于抗生素，尤其是 β-内酰胺类、化疗药物和单克隆抗体。专家意见：儿科过敏症专家应与传染病和肿瘤血液学专家合作，为有需要的儿童提供 DDS。仍然需要标准化的协议和国际指南来优化这种治疗并在临床日常实践中实施。