Actin is a major cytoskeletal element involved in multiple cellular processes. Actin‐rich regions present along the neuronal process aid in neuronal function, mediating multiple events involved in organelle trafficking. Actin is involved in organelle biogenesis, transport, and anchoring at specific locations. These functions can potentially be regulated by actin in a myosin‐dependent or myosin‐independent manner. The actin network could aid in membrane remodeling through membrane constriction, motor dependent transport, polymerization‐based transport, cargo anchoring, and halting of cargo by acting as a physical barrier. Additionally, actin dynamics is perturbed in some neurodegenerative diseases where it could impact organelle biogenesis, transport, or anchoring thereby contributing to progression of disease phenotypes. The role of actin and myosin in organelle trafficking is the primary focus of this review.

中文翻译：

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肌动蛋白在神经元细胞器运输中的作用。

肌动蛋白是参与多个细胞过程的主要细胞骨架成分。沿神经元过程存在的富含肌动蛋白的区域有助于神经元功能，介导与细胞器运输有关的多个事件。肌动蛋白参与细胞器的生物发生，运输和锚定在特定位置。这些功能可能由肌动蛋白以依赖肌球蛋白或不依赖肌球蛋白的方式调节。肌动蛋白网络可通过充当物理屏障，通过膜收缩，依赖于马达的运输，基于聚合的运输，货物锚固和货物暂停来帮助进行膜重塑。此外，肌动蛋白动力学在某些神经退行性疾病中会受到干扰，可能会影响细胞器的生物发生，运输或锚定，从而促进疾病表型的发展。