Hyperparathyroidism (HPT), including normocalcaemic, vitamin D sufficient (Serum (S)-25(OH)D ≥ 50 nmol/L) hyperparathyroidism (nHPT), has increasingly been diagnosed in the last few decades due to the more common use of the serum parathyroid hormone (S-PTH) assay. We investigated if men with HPT had higher morbidity and mortality than men without HPT during 21 years' follow-up.A random population sample of 750 men, all 50 years of age, was examined in 1993. Endpoints were retrieved 21 years later at 71 years of age.Albumin-corrected serum (S) calcium, S-25-hydroxyvitamin D and S-PTH were assessed along with data on cardiovascular risk factors and medication. Outcome data on fractures, stroke, myocardial infarction, cancer and death were retrieved in 2014; 21 years after primary assessment. The prevalence of HPT at 50 years of age was 9.3%; nHPT 2.8%, primary HPT 0.4%, secondary HPT 0.4%, and HPT with vitamin D insufficiency 6%. Fracture rate, myocardial infarction, stroke, cancer and death occurred similarly in men with or without HPT, as well as in men with nHPT as compared with men without calcium/PTH aberrations during 21 years' follow-up. S-PTH was evenly distributed in the univariable analyses for each outcome. Cox regression analyses showed no increase in serious morbidity or in mortality in men with HPT, irrespective of cause, compared with men with normal S-PTH over a 21-year period. None had HPT at a S-25(OH)D level of 100 nmol/L.

中文翻译：

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男性甲状旁腺功能亢进症-随访21年的发病率和死亡率。

在过去的几十年中，由于甲状旁腺功能亢进症的更广泛使用，越来越多的人被诊断出甲状旁腺功能亢进症（HPT），包括正常钙，维生素D充足（血清（S）-25（OH）D≥50 nmol / L）。血清甲状旁腺激素（S-PTH）测定。我们调查了在21年的随访中，患有HPT的男性是否比没有HPT的男性具有更高的发病率和死亡率。1993年对年龄50岁的750名男性进行了随机抽样调查。在21年后的71岁时进行了终点调查评估了白蛋白校正的血清（S）钙，S-25-羟基维生素D和S-PTH以及心血管危险因素和药物的数据。2014年获得了有关骨折，中风，心肌梗塞，癌症和死亡的结局数据；初次评估后21年。50岁时HPT的患病率为9.3％；nHPT 2.8％，主要HPT 0.4％，次要HPT 0.4％，以及维生素D功能不全的HPT 6％。在21年的随访中，有或没有HPT的男性以及nHPT的男性与没有钙/ PTH异常的男性相比，骨折率，心肌梗塞，中风，癌症和死亡的发生率相似。S-PTH在每个结果的单变量分析中均匀分布。Cox回归分析显示，与S-PTH正常的男性相比，HPT男性在21年内的严重发病率或死亡率没有增加，无论其原因如何。没有一个人的SPT（S-25（OH）D）水平为100 nmol / L。在21年的随访中，nHPT的男性与无钙/ PTH异常的男性相比。S-PTH在每个结果的单变量分析中均匀分布。Cox回归分析显示，与S-PTH正常的男性相比，HPT男性在21年内的严重发病率或死亡率没有增加，无论其原因如何。没有一个人的SPT（S-25（OH）D）水平为100 nmol / L。在21年的随访中，nHPT的男性与无钙/ PTH异常的男性相比。S-PTH在每个结果的单变量分析中均匀分布。Cox回归分析显示，与S-PTH正常的男性相比，HPT男性在21年内的严重发病率或死亡率没有增加，无论其原因如何。没有一个人的SPT（S-25（OH）D）水平为100 nmol / L。