Adiponectin is a 30 kDa protein hormone that has anti-atherogenic properties, being an insulin-sensitizing and anti-inflammatory molecule. Salivary adiponectin concentrations correlate positively with serum, thus, saliva was indicated as appropriate biofluid for its measurement in different clinical situations. However, inflammation was indicated as main confounding factor when evaluating the usefulness and the reliability of determination of salivary adiponectin. The aim of the present report was to evaluate the dynamics of salivary and serum adiponectin in systemic non-septic and septic inflammation using a dogs as a model. Forty bitches were enrolled. Seventeen dogs were healthy (group I, non-septic) and 23 bitches were diagnosed with pyometra (group II, septic). Ovariohysterectomy was performed for all animals. Saliva and blood samples were collected before (D0) and 3 (D3) and 10 (D10) days after ovariohysterectomy. At D0, Group I showed higher serum and salivary adiponectin than group II, although statistical significance was only detected in salivary adiponectin between the two groups at D0 (P = 0.001). In serum, adiponectin was higher on D0 than on D3 and tended to reach pre-surgery values on D10 in both groups. Salivary adiponectin showed similar behaviour to serum in Group I, while in group II salivary adiponectin concentrations were lowest on D0 and tended to increase on D3 and D10. The data obtained in present study describe for the first time the comparative behavior of salivary adiponectin in non-septic and septic inflammation. Salivary, and not serum, adiponectin seemed to mimic better the inflammatory and general health status.

中文翻译：

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犬模型中感染性和非感染性系统性炎症的血清和唾液脂联素动力学。

脂联素是一种30 kDa的蛋白质激素，具有抗动脉粥样硬化特性，是一种胰岛素敏感和抗炎分子。唾液脂联素浓度与血清呈正相关，因此，唾液被认为是适合在不同临床情况下进行测量的生物流体。但是，在评估唾液脂联素测定的有效性和可靠性时，炎症是主要的混杂因素。本报告的目的是使用狗作为模型，评估唾液和血清脂联素在全身性非脓毒性和脓毒性炎症中的动力学。招募了四十只母狗。十七只狗是健康的（I组，非败血性），而23个母犬被诊断出脓毒症（II组，化脓性）。对所有动物进行卵巢子宫切除术。在卵巢子宫切除术之后（D0），3（D3）和10（D10）天之前收集唾液和血液样本。在D0，I组的血清和唾液脂联素高于II组，尽管在D0两组之间的唾液脂联素只有统计学意义（P = 0.001）。在血清中，两组的脂联素在D0均高于D3，并且倾向于在D10达到术前值。唾液脂联素在I组中表现出与血清相似的行为，而在II组中，唾液脂联素浓度在D0时最低，而在D3和D10时趋于增加。本研究中获得的数据首次描述了唾液脂联素在非败血性和败血性炎症中的比较行为。唾液脂联素似乎不是唾液，而不是血清，可以更好地模拟炎症和总体健康状况。