MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage-specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development.

中文翻译：

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小鼠产前发育过程中 microRNA 表达的动态。


MicroRNA (miRNA) 作为基因表达的转录后调节因子发挥着关键作用。 ENCODE 项目分析了小鼠胚胎发育过程中大量器官中 miRNA 的表达，并捕获了 785 种 miRNA 的表达动态。我们发现了不同的器官特异性和发育阶段特异性 miRNA 表达簇，随着胚胎发育的进行，器官特异性表达增加的总体模式。对小鼠和人类保守 miRNA 的比较分析表明，按器官类型而不是按物种的表达模式具有更强的聚类性。与 miRNA 表达簇相比，对信使 RNA 表达簇的分析确定了特定 miRNA 表达簇在抑制胚胎发育过程中表达这些 miRNA 的器官中其他发育程序特异的 mRNA 表达方面的潜在作用。我们的结果提供了最全面的 miRNA 表达时间进程，作为小鼠胚胎发育集成 ENCODE 参考数据集的一部分。