Objectives. We aimed to investigate the prevalence of restless leg syndrome (RLS) and exploring the contributing factors that affect the development of RLS in Parkinson’s disease (PD) patients. Methods. A cross-sectional study was conducted consisting of 178 consecutive PD patients from our hospital between October 2015 and August 2016. We divided the participants into two groups, which were PD with RLS and PD with non-RLS. Then, we recorded their demographics and clinical data to draw a comparison between PD with RLS and PD with non-RLS. Results. 23 (12.92%) were diagnosed with RLS among all the enrolled PD patients. Unified Parkinson’s Disease Rating Scale III (UPDRS III) and Hamilton Depression Scale (HAMD) scores, probable rapid eye movement sleep behavior disorder (PRBD), and daily levodopa equivalent dose (LED) in the PD with the RLS group were significantly different from those in the PD with the non-RLS group. Daily LED and the scores of UPDRS III and HAMD in PD patients with RLS were all higher than those in PD patients with non-RLS. PRBD, daily LED, and HAMD scores were significantly independent factors contributing to the development of RLS (, 95% CI 1.372~15.944, ; , 95% CI 1.001~1.005, ; , 95% CI 1.002~1.193, ). The severity of RLS was positively correlated with the duration of PD and daily LED (, ; , ). Conclusion. PRBD existence, daily LED, and HAMD scores are independent factors for developing RLS in PD patients. PRBD existence is firstly proposed as an independent factor in developing RLS among PD patients. RLS severity in PD patients are positively associated with the duration of PD and daily LED.

中文翻译：

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可能的 RBD 与帕金森病中 RLS 的发展有关：一项横断面研究。

目标。我们旨在调查不宁腿综合征 (RLS) 的患病率，并探索影响帕金森病 (PD) 患者 RLS 发展的促成因素。方法。在 2015 年 10 月至 2016 年 8 月期间，我们对来自我院的 178 名连续 PD 患者进行了一项横断面研究。我们将参与者分为两组，即 PD 合并 RLS 和 PD 合并非 RLS。然后，我们记录了他们的人口统计学和临床​​数据，以比较 PD 与 RLS 和 PD 与非 RLS。结果. 在所有登记的 PD 患者中，23 名 (12.92%) 被诊断为 RLS。RLS组PD的统一帕金森病评定量表III（UPDRS III）和汉密尔顿抑郁量表（HAMD）评分、可能的快速眼动睡眠行为障碍（PRBD）和每日左旋多巴当量剂量（LED）与那些有显着差异在非 RLS 组的 PD 中。伴有RLS的PD患者每日LED及UPDRS III、HAMD评分均高于非RLS的PD患者。PRBD、每日 LED 和 HAMD 评分是导致 RLS 发展的显着独立因素。, 95% CI 1.372~15.944,; , 95% CI 1.001~1.005,; , 95% CI 1.002~1.193,）。RLS 的严重程度与 PD 持续时间和每日 LED 呈正相关（, ; , ）。 结论。PRBD 存在、每日 LED 和 HAMD 评分是 PD 患者发生 RLS 的独立因素。PRBD 的存在首先被认为是 PD 患者发生 RLS 的独立因素。PD 患者的 RLS 严重程度与 PD 持续时间和每日 LED 呈正相关。