BACKGROUND The measurement of native T1 through cardiovascular magnetic resonance (CMR) is a noninvasive method of assessing myocardial fibrosis without gadolinium contrast. No studies so far have evaluated native T1 after renal transplantation. The primary aim of the current study is to assess changes in the myocardium native T1 6 months after renal transplantation. METHODS We prospectively evaluated 44 renal transplant patients with 3 T CMR exams: baseline at the beginning of transplantation and at 6 months after transplantation. RESULTS The native T1 time was measured in the midventricular septum and decreased significantly from 1331 ± 52 ms at the baseline to 1298 ± 42 ms 6 months after transplantation (p = 0.001). The patients were split into two groups through a two-step cluster algorithm: In cluster-1 (n = 30) the left ventricular (LV) mass index and the prevalence of diabetes were lower. In cluster-2 (n = 14) the LV mass index and diabetes prevalence were higher. Decrease in native T1 values was significant only in the patients in cluster-1 (p = 0.001). CONCLUSIONS The native myocardial T1 time decreased significantly 6 months after renal transplant, which may be associated with the regression of the reactive fibrosis. The patients with greater baseline LV mass index and the diabetic group did not reach a significant decrease in T1.

中文翻译：

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肾移植与减少心肌纤维化有关。使用天然 T1 映射进行心血管磁共振研究。


背景技术通过心血管磁共振（CMR）测量天然T1是一种无需钆造影剂即可评估心肌纤维化的无创方法。迄今为止还没有研究评估肾移植后的天然 T1。当前研究的主要目的是评估肾移植后 6 个月心肌天然 T1 的变化。方法 我们对 44 名肾移植患者进行了 3 次 T CMR 检查前瞻性评估：移植开始时和移植后 6 个月时的基线。结果 测量心室中间隔处的自然 T1 时间，从基线时的 1331 ± 52 ms 显着下降至移植后 6 个月的 1298 ± 42 ms（p = 0.001）。通过两步聚类算法将患者分为两组：在聚类 1 (n = 30) 中，左心室 (LV) 质量指数和糖尿病患病率较低。在集群 2 (n = 14) 中，左心室质量指数和糖尿病患病率较高。原始 T1 值的下降仅在簇 1 中的患者中显着 (p = 0.001)。结论肾移植后6个月原生心肌T1时间显着缩短，这可能与反应性纤维化的消退有关。基线 LV 质量指数较高的患者和糖尿病组的 T1 并未显着下降。