Regional differences between people who inject drugs in an HIV prevention trial integrating treatment and prevention (HPTN 074): a baseline analysis,Journal of the International AIDS Society

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Regional differences between people who inject drugs in an HIV prevention trial integrating treatment and prevention (HPTN 074): a baseline analysis
Journal of the International AIDS Society ( IF 4.6 ) Pub Date : 2018-10-01 , DOI: 10.1002/jia2.25195
Kathryn E Lancaster ₁ , Irving F Hoffman ₂ , Brett Hanscom ₃ , Tran Viet Ha ₄ , Kostyantyn Dumchev ₅ , Hepa Susami ₆ , Scott Rose ₇ , Vivian F Go ₄ , Sarah A Reifeis _{8,

9} , Katie R Mollan ₉ , Michael G Hudgens _{8,

9} , Estelle M Piwowar-Manning ₁₀ , Paul Richardson ₁₀ , Sergii Dvoriak _{5,

11} , Zubairi Djoerban ₆ , Tetiana Kiriazova ₅ , Oleksandr Zeziulin ₅ , Samsuridjal Djauzi ₆ , Chu Viet Ahn ₁₂ , Carl Latkin ₁₃ , David Metzger ₁₄ , David N Burns ₁₅ , Jeremy Sugarman ₁₆ , Steffanie A Strathdee ₁₇ , Susan H Eshleman ₁₀ , William Clarke ₁₀ , Deborah Donnell ₃ , Lynda Emel ₃ , Lisa E Sunner ₃ , Laura McKinstry ₃ , Nirupama Sista ₇ , Erica L Hamilton ₇ , Jonathan P Lucas ₇ , Bui D Duong ₁₈ , Nguyen Van Vuong ₁₉ , Riza Sarasvita ₂₀ , William C Miller ₁ ,

Affiliation

Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.
Division of Infectious Diseases, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
SCHARP-FHCRC, Seattle, WA, USA.
Department of Health Behavior, Gilings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ukrainian Institute on Public Health Policy, Kyiv, Ukraine.
University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
FHI 360, Durham, NC, USA.
Department of Biostatistics, Gilings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for AIDS Research (CFAR), School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine.
UNC Project, Hanoi, Vietnam.
Department of Health, Behavior, and Society, Johns Hopkins University, Baltimore, MD, USA.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Division of AIDS, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health, Bethesda, MD, USA.
Department of Medicine, Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
Department of Medicine, School of Medicine, University of California San Diego, San Diego, CA, USA.
Vietnam Authority of HIV/AIDS Control - Ministry of Health, Hanoi, Vietnam.
Pho Yen Health District Center, Pho Yen, Vietnam.
National Narcotic Board, Jakarta, Indonesia.

People who inject drugs (PWID) experience high HIV incidence and face significant barriers to engagement in HIV care and substance use treatment. Strategies for HIV treatment as prevention and substance use treatment present unique challenges in PWID that may vary regionally. Understanding differences in the risk structure for HIV transmission and disease progression among PWID is essential in developing and effectively targeting intervention strategies of HIV treatment as prevention.

中文翻译：

在治疗和预防相结合的艾滋病毒预防试验中注射吸毒者之间的区域差异（HPTN 074）：基线分析

注射吸毒者 (PWID) 的艾滋病毒感染率很高，并且在参与艾滋病毒护理和药物滥用治疗方面面临重大障碍。作为预防和药物滥用治疗的艾滋病毒治疗策略对吸毒者提出了独特的挑战，这些挑战可能因地区而异。了解吸毒者之间艾滋病毒传播和疾病进展的风险结构差异对于制定和有效针对艾滋病毒治疗作为预防的干预策略至关重要。

更新日期：2018-10-01

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