OBJECTIVES The aim of this randomized controlled clinical trial was to evaluate the possible advantages of adjunctive hyaluronic acid (HA) application in the coronally advanced flap (CAF) procedure in single Miller class I/recession type 1 (RT1) gingival recession treatment. MATERIAL AND METHODS Thirty patients with one recession were enrolled; 15 were randomly assigned CAF + HA and 15 to CAF alone. The recession reduction (RecRed), clinical attachment level gain (CAL-gain), changes in probing pocket depth (PPD) and in the width of keratinized tissue (KT), complete root coverage (CRC), and mean root coverage (MRC) were calculated after 18 months. Post-operative morbidity (pain intensity, discomfort, and swelling) was recorded 7 days after treatment using visual analogue scale (VAS). RESULTS After 18 months, RecRed was statistically significantly higher in the test group (2.7 mm [1.0]) than in the control group (1.9 mm [1.0]; p = 0.007). PPD were found to be slightly but statistically significantly increased in both groups. No statistically significant difference was found for KT gain between treatments. CRC was 80% for test and 33.3% for control sites (p < 0.05). A MRC of 93.8 ± 13.0% for test and 73.1 ± 20.8% for control sites was calculated (p < 0.05). The test group reported lower swelling and discomfort values 7-days post-surgery (p < 0.05). Statistically significant difference was not found for pain intensity. CONCLUSIONS The adjunctive use of HA was effective in obtaining CRC for single Miller class I/RT1 gingival recession sites. CLINICAL RELEVANCE Adjunctive application of HA in the coronally advanced flap procedure may improve the reduction of the recessions and increase the probability of CRC in Miller class I recessions.

中文翻译：

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辅助透明质酸在米勒I类单牙龈退缩部位的冠状晚期皮瓣中的应用效果：一项随机对照临床试验。

目的这项随机对照临床试验的目的是评估辅助透明质酸（HA）在单一Miller I类/衰退1型（RT1）牙龈凹陷治疗中的冠状动脉高级皮瓣（CAF）手术中的可能优势。材料与方法纳入30例患有1次衰退的患者。15人被随机分配为CAF + HA，15人被单独分配为CAF。衰退减少（RecRed），临床附着水平增加（CAL-gain），探查袋深度（PPD）和角化组织宽度（KT）的变化，完全根覆盖（CRC）和平均根覆盖（MRC）在18个月后计算。治疗后7天，使用视觉模拟量表（VAS）记录术后发病率（疼痛强度，不适和肿胀）。结果18个月后，试验组的RecRed（2.7 mm [1.0]）显着高于对照组（1.9 mm [1.0]； p = 0.007）。发现两组的PPD略有增加，但统计学上显着增加。治疗之间的KT增加没有统计学上的显着差异。测试的CRC率为80％，对照部位的CRC为33.3％（p <0.05）。测试的MRC为93.8±13.0％，对照部位的MRC为73.1±20.8％（p <0.05）。测试组报告，术后7天的肿胀和不适感值较低（p <0.05）。疼痛强度未发现统计学上的显着差异。结论HA的辅助使用可有效获得单个Miller I / RT1类牙龈退缩部位的CRC。