The association between serum uric acid levels and human disease has garnered intense interest over the last decade including chronic kidney disease. Animal studies have provided evidence for a potential mechanistic role of uric acid in promoting progression of chronic kidney disease. Epidemiologic studies have also suggested an association between elevated serum uric acid levels and worsening renal function in the general population as well as in patients with chronic kidney disease. However, there is currently insufficient evidence to recommend the use of uric acid-lowering therapy to delay progression of chronic kidney disease in this patient population. Adequately powered, randomized, placebo-controlled trials are required to more precisely evaluate the risk and benefits of uric acid-lowering therapy in pediatric patients.

中文翻译：

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尿酸与慢性肾脏疾病的进展。

在过去的十年中，血清尿酸水平与人类疾病之间的联系引起了广泛的关注，包括慢性肾脏疾病。动物研究提供了尿酸在促进慢性肾脏疾病进展中潜在的机械作用的证据。流行病学研究还表明，在普通人群以及患有慢性肾脏疾病的患者中，血清尿酸水平升高与肾功能恶化之间存在关联。但是，目前没有足够的证据推荐使用降尿酸治疗来延缓该患者人群中慢性肾脏疾病的进展。需要更充分，随机，安慰剂对照的试验来更准确地评估小儿患者降低尿酸治疗的风险和益处。