Xenotropic murine leukemia virus-related virus (XMRV) is a novel retrovirus, related to murine leukemia virus (MLV), that has been implicated in human disease. If XMRV is indeed able to replicate in humans, then one might predict that XMRV would have developed resistance to human innate antiviral resistance factors such as APOBEC3G (hA3G). In fact, we observed that XMRV and MLV are both highly sensitive to inhibition by hA3G and equally resistant to inhibition by murine APOBEC3. While several human prostate cancer cell lines were found to lack hA3G, stable expression of physiological levels of hA3G rendered these cells refractory to XMRV replication. Few human tissues fail to express hA3G, and we therefore hypothesize that XMRV replicates in one or more hA3G-negative reservoir tissues and/or that human XMRV infections are likely to be rare and potentially of zoonotic origin.

中文翻译：

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人APOBEC3蛋白可以抑制异种鼠白血病病毒相关病毒的感染性。


异嗜性鼠白血病病毒相关病毒 (XMRV) 是一种新型逆转录病毒，与鼠白血病病毒 (MLV) 相关，与人类疾病有关。如果 XMRV 确实能够在人类中复制，那么人们可能会预测 XMRV 会对人类先天抗病毒耐药因子（如 APOBEC3G (hA3G)）产生耐药性。事实上，我们观察到 XMRV 和 MLV 都对 hA3G 的抑制高度敏感，并且对鼠 APOBEC3 的抑制具有同样的抵抗力。虽然发现几种人前列腺癌细胞系缺乏 hA3G，但 hA3G 生理水平的稳定表达使这些细胞难以进行 XMRV 复制。很少有人类组织不能表达 hA3G，因此我们假设 XMRV 在一种或多种 hA3G 阴性储存组织中复制和/或人类 XMRV 感染可能很罕见，并且可能具有人畜共患起源。