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Postural impairments in Parkinson's disease are not associated with changes in circadian rhythms changes.
Chronobiology International ( IF 2.2 ) Pub Date : 2019-11-25 , DOI: 10.1080/07420528.2019.1692350
Luiz Claudio Zulai 1 , André Martinez Albuquerque 2 , Caluê Papcke 1 , Fernando Mazzilli Louzada 3 , Eduardo Mendonça Scheeren 1
Affiliation  

Parkinson's disease (PD) is a progressive neurodegenerative disease, with a worldwide incidence of 1% in individuals >60 years of age. Its primary characteristics include postural impairments and changes in circadian rhythms. The authors investigated the association between postural impairment and changes in circadian rhythms in 24 PD subjects diagnosed with stages 1 to 3 on the Hoehn-Yard (HY) scale and regularly used dopaminergic medication for at least 1 year (experimental group - EG) and 24 healthy elderly individuals without a history of neurological impairment as the control group (CG). Static balance tests using a force plate were performed, and activity/rest rhythm, according to the relative amplitude of L5 and M10 values, was monitored for seven consecutive days using actimetry. The results indicated differences in posturographic indicators of mediolateral displacement (ML) [EG, 4.71 ± 0.85 mm; CG, 2.79 ± 0.53 mm (p < .0001)] and anteroposterior displacement of the center of pressure (COP) [EG, 5.61 ± 2.43 mm; CG, 8.23 ± 1.72 mm (< 0.0001)], ML velocity of the COP [EG, 2.39 ± 0.83 mm/s; CG, 1.40 ± 0.18 mm/s (p < .0001)], and total distance of the COP in the tandem stance condition [EG, 227.6 ± 75 mm; CG, 53.4 ± 6.1 mm (p < .0001)] between the EG and CG. There was no correlation between relative amplitude and posturographic data for the EG. Postural impairments were verified in comparing the EG and CG; however, there was no association between posturographic indicators and activity/rest rhythm.

中文翻译:

帕金森病的姿势障碍与昼夜节律变化无关。

帕金森病 (PD) 是一种进行性神经退行性疾病,全球 60 岁以上人群的发病率为 1%。其主要特征包括姿势障碍和昼夜节律的变化。作者调查了 24 名被诊断为 Hoehn-Yard (HY) 量表 1 至 3 期并经常使用多巴胺能药物至少 1 年(实验组 - EG)和 24没有神经功能障碍病史的健康老年人作为对照组(CG)。使用测力板进行静态平衡测试,并根据 L5 和 M10 值的相对幅度,使用活动测定法连续 7 天监测活动/休息节律。结果表明内侧位移 (ML) [EG, 4.71 ± 0.85 mm; CG, 2.79 ± 0.53 mm (p < .0001)] 和压力中心的前后位移 (COP) [EG, 5.61 ± 2.43 mm; CG, 8.23 ± 1.72 mm (< 0.0001)], COP 的 ML 速度 [EG, 2.39 ± 0.83 mm/s; CG, 1.40 ± 0.18 mm/s (p < .0001)],以及串联站立条件下 COP 的总距离 [EG, 227.6 ± 75 mm; CG, 53.4 ± 6.1 mm (p < .0001)] 在 EG 和 CG 之间。EG 的相对振幅和姿势图数据之间没有相关性。在比较 EG 和 CG 时验证了姿势障碍;然而,姿势指标与活动/休息节奏之间没有关联。0001)] 和压力中心的前后位移 (COP) [EG, 5.61 ± 2.43 mm; CG, 8.23 ± 1.72 mm (< 0.0001)], COP 的 ML 速度 [EG, 2.39 ± 0.83 mm/s; CG, 1.40 ± 0.18 mm/s (p < .0001)],以及串联站立条件下 COP 的总距离 [EG, 227.6 ± 75 mm; CG, 53.4 ± 6.1 mm (p < .0001)] 在 EG 和 CG 之间。EG 的相对振幅和姿势图数据之间没有相关性。在比较 EG 和 CG 时验证了姿势障碍;然而,姿势指标与活动/休息节奏之间没有关联。0001)] 和压力中心的前后位移 (COP) [EG, 5.61 ± 2.43 mm; CG, 8.23 ± 1.72 mm (< 0.0001)], COP 的 ML 速度 [EG, 2.39 ± 0.83 mm/s; CG, 1.40 ± 0.18 mm/s (p < .0001)],以及串联站立条件下 COP 的总距离 [EG, 227.6 ± 75 mm; CG, 53.4 ± 6.1 mm (p < .0001)] 在 EG 和 CG 之间。EG 的相对振幅和姿势图数据之间没有相关性。在比较 EG 和 CG 时验证了姿势障碍;然而,姿势指标与活动/休息节奏之间没有关联。CG, 53.4 ± 6.1 mm (p < .0001)] 在 EG 和 CG 之间。EG 的相对振幅和姿势图数据之间没有相关性。在比较 EG 和 CG 时验证了姿势障碍;然而,姿势指标与活动/休息节奏之间没有关联。CG, 53.4 ± 6.1 mm (p < .0001)] 在 EG 和 CG 之间。EG 的相对振幅和姿势图数据之间没有相关性。在比较 EG 和 CG 时验证了姿势障碍;然而,姿势指标与活动/休息节奏之间没有关联。
更新日期:2019-11-01
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