The mechanistic target of rapamycin (mTOR) is a major signaling hub that coordinates cellular and organismal responses, such as cell growth, proliferation, apoptosis, and metabolism. Dysregulation of mTOR signaling occurs in many human diseases, and there are significant ongoing efforts to pharmacologically target this pathway. Long noncoding RNAs (lncRNA), defined by a length > 200 nucleotides and absence of a long open-reading-frame, are a class of non-protein-coding RNAs. Mutations and dysregulations of lncRNAs are directly linked to the development and progression of many diseases, including cancer, diabetes, and neurologic disorders. Recent findings reveal diverse functions for lncRNA that include transcriptional regulation, organization of nuclear domains, and regulation of proteins or RNA molecules. Despite considerable development in our understanding of lncRNA over the past decade, only a fraction of annotated lncRNAs has been examined for biological function. In addition, lncRNAs have emerged as therapeutic targets due to their ability to modulate multiple pathways, including mTOR signaling. This review will provide an up-to-date summary of lncRNAs that are involved in regulating mTOR pathway.

中文翻译：

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长非编码RNA对mTOR信号的调节。

雷帕霉素（mTOR）的机制靶标是主要的信号枢纽，可协调细胞和生物的反应，例如细胞的生长，增殖，凋亡和代谢。mTOR信号转导的失调发生在许多人类疾病中，并且正在进行大量的药理学研究，以针对该途径进行研究。长非编码RNA（lncRNA）是一类非蛋白质编码RNA，其定义为长度大于200个核苷酸且没有长的开放阅读框。lncRNA的突变和失调与许多疾病（包括癌症，糖尿病和神经系统疾病）的发生和发展直接相关。最近的发现揭示了lncRNA的多种功能，包括转录调控，核结构域的组织以及蛋白质或RNA分子的调控。尽管在过去十年中我们对lncRNA的理解有了长足的发展，但仅检查了一部分带注释的lncRNA的生物学功能。此外，lncRNA由于其调节多种途径（包括mTOR信号传导）的能力而成为治疗靶点。这篇综述将提供参与调节mTOR途径的lncRNA的最新摘要。