PURPOSE To assess the utility of furosemide diuresis and the role of an improved scatter correction algorithm in reducing scatter artifact severity on Ga-68- Prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET). MATERIALS AND METHODS A total of 139 patients underwent Ga-68-PSMA-11 PET imaging for prostate cancer: 47 non-time-of-flight (non-TOF) PET/computed tomography, 51 PET/magnetic resonance imaging (MRI) using the standard TOF scatter correction algorithm, and 41 PET/MRI using an improved TOF scatter correction algorithm. Whole-body PET acquisitions were subdivided into 3 regions: around kidneys; between kidneys and bladder; and around bladder. The images were reviewed, and scatter artifact severity was rated using a Likert-type scale. RESULTS The worst scatter occurred when using non-TOF scatter correction without furosemide, where 42.1% of patients demonstrated severe scatter artifacts in 1 or more regions. Improved TOF scatter correction resulted in the smallest percentage of studies with severe scatter (6.5%). Scatter ratings by region were lowest using improved TOF scatter correction. Furosemide reduced mean scatter severity when using non-TOF and standard TOF. CONCLUSIONS Both furosemide and scatter correction algorithm play a role in reducing scatter in PSMA PET. Improved TOF scatter correction resulted in the lowest scatter severity.

中文翻译：

---

Ga-68-PSMA-11 PET 的散射伪影：呋塞米利尿和改进的散射校正可降低严重程度。


目的 评估呋塞米利尿的效用以及改进的散射校正算法在降低 Ga-68-前列腺特异性膜抗原 (PSMA)-11 正电子发射断层扫描 (PET) 散射伪影严重性方面的作用。材料和方法 共有 139 名患者接受了前列腺癌的 Ga-68-PSMA-11 PET 成像：47 名患者使用非飞行时间 (non-TOF) PET/计算机断层扫描，51 名患者使用 PET/磁共振成像 (MRI)标准 TOF 散射校正算法，以及使用改进的 TOF 散射校正算法的 41 PET/MRI。全身 PET 采集被细分为 3 个区域：肾脏周围；肾脏和膀胱之间；和膀胱周围。对图像进行审查，并使用李克特型量表对散射伪影的严重程度进行评级。结果 当使用不使用速尿的非 TOF 散射校正时，散射最严重，其中 42.1% 的患者在 1 个或多个区域表现出严重的散射伪影。改进的 TOF 散射校正使严重散射的研究比例最小 (6.5%)。使用改进的 TOF 散射校正，按区域划分的散射评级最低。使用非 TOF 和标准 TOF 时，呋塞米可降低平均散射严重程度。结论 呋塞米和散射校正算法都对减少 PSMA PET 中的散射起到了作用。改进的 TOF 散射校正可实现最低的散射严重程度。