Accumulating research indicates oxytocin plays a significant role in regulating the behavioral and neurobiological responses to stress. Evidence from preclinical models suggests the effect of oxytocin on stress-responsivity appears to be dependent on individual characteristics, including sex. Although the interaction between oxytocinergic and stress systems has been widely studied in rodents, recent efforts have been made to examine the interface between these two systems in humans. This brief review examines how administration of oxytocin can influence the neuroendocrine, behavioral, and neural responses to stress, explores how sex may impact these effects, and provides considerations for future work.

越来越多的研究表明催产素在调节对压力的行为和神经生物学反应中起着重要作用。临床前模型的证据表明催产素对应激反应的影响似乎取决于包括性别在内的个体特征。尽管在啮齿动物中已经广泛研究了催产素能与应激系统之间的相互作用，但最近人们已经在努力研究人体中这两种系统之间的界面。这篇简短的综述研究了催产素的给药如何影响神经内分泌，行为和神经对压力的反应，探讨了性行为如何影响这些作用，并为以后的工作提供了考虑。