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Pattern of uncontrolled allergic rhinitis in a hospital setting of Kinshasa, Democratic Republic of Congo
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2019-09-18 , DOI: 10.1002/iid3.272 Patricia K Kakobo 1 , Hilaire K Kalala 1 , Maguy M Tshibola 1 , Joseph K Kelekele 2 , Dieudonné T Nyembue 1 , Peter W Hellings 3, 4, 5
Abstract Aim To determine the clinical and allergic features of uncontrolled allergic rhinitis (UCAR) in the Democratic Republic of Congo (DRC).Methods Observational cross‐sectional study of 311 patients with UCAR. Allergic rhinitis was diagnosed clinically with sensitization to inhalant allergens and then confirmed by skin prick test. Severity was assessed using the Visual Analog Scale (VAS), with VAS scores greater than or equal to 5 used as cut off to determine uncontrolled status.Results The mean age of UCAR patients was 30.7 ± 15.1 years and 66.9% of the patients were females. Three out of four patients had persistent UCAR while the remainder had intermittent symptoms. UCAR was associated with rhinosinusitis and asthma in 18.6% and 18% of the patients, respectively. Among UCAR patients, 95.2% were polysensitized. The allergens most frequently involved were mites (82%), cat (27.3%), and dog (26.7%). The most frequent symptoms were nasal congestion, sneezing, and runny nose. There were 44.4% of the patients treated with nasal corticosteroids and 33.1% with oral antihistamine (anti‐H1).Conclusions This study reports on the clinical phenotype of UCAR in the DRC. The findings contribute to our understanding of UCAR in this population and may be used to implement strategies to reduce the prevalence and burden of UCAR in this setting.
中文翻译:
刚果民主共和国金沙萨医院内不受控制的过敏性鼻炎模式
摘要 目的 旨在确定刚果民主共和国 (DRC) 不受控制的过敏性鼻炎 (UCAR) 的临床和过敏特征。方法 311 名 UCAR 患者的观察性横断面研究。过敏性鼻炎临床上诊断为对吸入性过敏原过敏,然后通过皮肤点刺试验确诊。使用视觉模拟量表(VAS)评估严重程度,VAS 分数大于或等于 5 用作确定不受控制状态的截止值。结果 UCAR患者的平均年龄为30.7±15.1岁,其中66.9%的患者为女性。四分之三的患者患有持续性 UCAR,而其余患者则有间歇性症状。UCAR 分别与 18.6% 和 18% 的患者鼻窦炎和哮喘相关。在 UCAR 患者中,95.2% 是多敏的。最常见的过敏原是螨虫(82%)、猫(27.3%)和狗(26.7%)。最常见的症状是鼻塞、打喷嚏和流鼻涕。44.4% 的患者接受鼻用皮质类固醇治疗,33.1% 的患者接受口服抗组胺药(抗 H1)治疗。结论 本研究报告了刚果民主共和国 UCAR 的临床表型。这些发现有助于我们了解该人群中的 UCAR,并可用于实施减少该人群中 UCAR 患病率和负担的策略。
更新日期:2019-09-18
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2019-09-18 , DOI: 10.1002/iid3.272 Patricia K Kakobo 1 , Hilaire K Kalala 1 , Maguy M Tshibola 1 , Joseph K Kelekele 2 , Dieudonné T Nyembue 1 , Peter W Hellings 3, 4, 5
Affiliation
中文翻译:
刚果民主共和国金沙萨医院内不受控制的过敏性鼻炎模式