AbstractThe natural history of large local reactions to Hymenoptera stings allowed to estimate the risk to develop a systemic reaction after an initial large local reaction in about 4% of patients. A recently published study claimed that such risk concerns instead around one‐fourth of patients. However, such study is flawed by serious imprecision, particularly the unreliable identification by patients of the culprit insect, as well as the dubious identification of the causative venom in multisensitized patients. Also, the authors criticized previous studied because of the limited number of patients, while they included in the study 662 patients. Indeed, when only patients clearly restung by the same insect according to their history data were considered, the number of patients fell to 35. These data are unable to change the current shared concept on the low risk of systemic reactions in patients with initial large local reaction.

中文翻译：

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当地对膜翅目昆虫蜇伤的强烈反应：需要进行合理的研究来改变共同的概念

摘要膜翅目昆虫蜇伤引起的大规模局部反应的自然史可以估计约 4% 的患者在最初发生大规模局部反应后发生全身反应的风险。最近发表的一项研究声称，大约四分之一的患者存在这种风险。然而，此类研究存在严重不精确的缺陷，特别是患者对罪魁祸首昆虫的识别不可靠，以及对多重过敏患者的致病毒液的识别也很可疑。此外，作者还批评了之前的研究，因为他们的研究纳入了 662 名患者，但患者数量有限。事实上，当仅考虑根据病史数据明确被同一昆虫叮咬过的患者时，患者数量下降至 35 例。这些数据无法改变目前关于初始局部大面积患者全身反应风险低的共同观念。反应。