In children conventional hemodialysis does not often improve growth. We determined linear growth in five children on in-center intensified and daily hemodialysis (IDd) regimen, with a mean age of 8 years 7 months at enrollment. Four of five were on growth hormone started for a median of 28.5 months before IDd. IDd was delivered 5 to 6 times weekly, for three hours each session. Mean follow up of IDd was 18.6 months. Dropout from IDd was kidney transplantation (n=4) or transfer to another center (n=1). IDd and free diet improved appetite, thereby protein intake, was above 2 g/kg/BW. Median weekly Kt/V(urea) was 9.1 (8.7 to 10.4). Predialysis phosphorus blood levels were higher at the start (2.04+/-0.34 mmol/L) than at end of IDd (1.39+/-0.41 mmol/L) without need for carbonate of calcium in four of five cases. During conventional dialysis ht SDS decreased from -0.8 to -1.44, which occurred predominantly before rhGH start. Conversion to IDd significantly increased growth velocity to a mean of 13 cm/year (10.3-18) with a mean change of +1.84 ht SDS/year (0.4 to 2.7). This preliminary report suggests the potential efficacy of IDd regimen in promising growth velocity, either directly from a higher dialysis dose or indirectly through an improved nutritional status.

中文翻译：

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加强和每天进行儿童血液透析可能会改善体格发育。

在儿童中，常规血液透析通常不能改善生长。我们确定了五个儿童在中心强化和每日血液透析（IDd）方案下的线性生长，入组时的平均年龄为8岁7个月。五分之四的人在IDd之前服用生长激素，中位时间为28.5个月。IDd每周分发5至6次，每次会话三个小时。IDd的平均随访时间为18.6个月。IDd的退出是肾脏移植（n = 4）或转移到另一个中心（n = 1）。IDd和自由饮食改善食欲，从而蛋白质摄入高于2g / kg / BW。每周Kt / V（尿素）的中位数为9.1（8.7至10.4）。在五分之四的病例中，透析前的磷水平在开始时（2.04 +/- 0.34 mmol / L）高于在IDd结束时（1.39 +/- 0.41 mmol / L），而无需添加碳酸钙。在常规透析过程中，ht SDS从-0.8降至-1.44，这主要发生在rhGH开始之前。转换为IDd显着提高了生长速度，使其平均速度达到13厘米/年（10.3-18），平均变化为+1.84 ht SDS /年（0.4至2.7）。该初步报告表明，IDd方案在有希望的生长速度中的潜在功效，可能直接来自较高的透析剂量，也可能间接来自改善的营养状况。