Since its discovery as a neurotrophic factor in retinal pigmented epithelium cells in the late 1980s, there has been an increase in understanding of the role that pigment epithelium-derived factor (PEDF) plays in cellular functions. PEDF plays an important role in mediating cellular protection during exposure to oxidative stress and inflammation by preventing stress-induced angiogenesis and apoptosis. PEDF acts to reduce oxidative stress by promoting mitochondrial stability and by regulating the expression of enzymes involved in ROS accumulation and clearance. PEDF protects against the negative effects of oxidative stress by regulating cell survival pathways and the expression of inflammatory and proangiogenic mediators. PEDF-mediated cellular protection may be of clinical importance in diseases characterised by oxidative stress, chronic inflammation and pathological neovascularization, indicating that targeting PEDF may be a potential focus for therapeutic interventions in chronic diseases. In this review, we provide a historical perspective on the discoveries of PEDF interactions and functions, and discuss recent in vitro, in vivo and clinical findings to provide a current summary of the important protective effects following cellular exposure to stress stimuli and future clinical potential of PEDF.

中文翻译：

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色素上皮衍生因子在抵抗细胞应激中的作用。

自从1980年代末发现它是视网膜色素上皮细胞的神经营养因子以来，人们对色素上皮衍生因子（PEDF）在细胞功能中所起的作用的了解日益增加。PEDF通过防止应激诱导的血管生成和凋亡在介导氧化应激和炎症过程中介导细胞保护中发挥重要作用。PEDF通过促进线粒体的稳定性和调节参与ROS积累和清除的酶的表达来减轻氧化应激。PEDF通过调节细胞存活途径以及炎性和促血管生成介质的表达来防止氧化应激的负面影响。PEDF介导的细胞保护在以氧化应激为特征的疾病中可能具有重要的临床意义，慢性炎症和病理性新生血管形成，表明靶向PEDF可能是慢性疾病治疗干预的潜在重点。在这篇综述中，我们提供了有关PEDF相互作用和功能发现的历史观点，并讨论了最近的体外，体内和临床发现，以提供细胞暴露于应激刺激后的重要保护作用的最新摘要以及该药物未来的临床潜力。 PEDF。