The goal of the current study was to investigate the protective effects of Gingko biloba extract EGB761 on heat-stressed chicken heart in vivo and its underlying relevance to Hsp70.Fifty, one-day-old female chicks were randomly divided into five groups: control (Con), heat-stress (HS), 0.1% EGB761 plus heat stress (0.1%EGB+HS), 0.3%EGB761 plus heat stress (0.3%EGB+HS), and 0.6%EGB761 plus heat stress (0.6%EGB+HS) groups. After administration of EGB761 for 45 days, the chickens in each group were exposed to a single heat stress event at 38 ± 1°C for 3 h.EGB761 attenuated the abnormal symptoms and pathological scores of myocardium of heat-stressed chickens. Despite a reduction in the transcription and translation of the Hsp70 gene in heat-stressed myocardium, EGB761 induced the expression of Hsp70 in endothelial cells of the microarteries and venules into the blood, and reduced heat-stress damage in vascular endothelial cells.Supplementation with EGB761 before heat stress exposure protected chicken myocardium from damage by increasing serum Hsp70 protein from myocardial cells and cardiac microvascular endothelial cells and protected the microvascular system from adverse injury.

中文翻译：

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银杏叶提取物 EGB761 通过在体内刺激血管内皮细胞中 Hsp70 的表达来减轻鸡心脏组织的热应激损伤。

本研究的目的是研究银杏叶提取物 EGB761 对体内热应激鸡心脏的保护作用及其与 Hsp70 的潜在相关性。将 50 只 1 日龄雌性小鸡随机分为五组：对照组（ Con)、热应力 (HS)、0.1% EGB761 加热应力 (0.1%EGB+HS)、0.3%EGB761 加热应力 (0.3%EGB+HS) 和 0.6%EGB761 加热应力 (0.6%EGB+ HS) 组。给予EGB761 45 d后，各组鸡在38±1℃单次热应激事件中暴露3 h。EGB761减轻热应激鸡的心肌异常症状和病理评分。尽管热应激心肌中 Hsp70 基因的转录和翻译减少，