PURPOSE To determine the number of days to positive CT-guided biopsy sample culture in patients with discitis-osteomyelitis. METHODS Our study was IRB approved and HIPAA compliant. All CT-guided biopsies performed for acute discitis-osteomyelitis with positive microbiology between 2002 and 2018 were reviewed. Microbiological organism and days to positive biopsy were documented. Mean, median, skew, and standard deviation were calculated. The proportion of positive cultures that become positive after each day has elapsed was also calculated. RESULTS There were 96 true positive cultures, with 64 (67%) male and 32 (33%) female, ages 57 ± 18 (range 19-87) years. Overall, including all culture results, the mean number of days to positive culture was 2.9 ± 3.5 days. The median number of days was 2, with a positive skew of 2.9. At days 1, 2, 3, 4, and 5, 48%, 68%, 78%, 85%, and 89%, respectively, of biopsy samples had a positive microbiology culture. CONCLUSION Approximately three-quarters of discitis-osteomyelitis pathogens will be identified by biopsy sample culture by 3 days after CT-guided biopsy. This finding should be considered if planning for a repeat biopsy in the setting of a negative microbiology culture.

中文翻译：

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CT引导的微生物学阴性的椎间盘炎-骨髓炎活检：在重复活检之前，我们应等待几天？

目的确定椎间盘炎-骨髓炎患者接受CT引导的活检样本培养阳性的天数。方法我们的研究获得IRB批准且符合HIPAA。回顾了2002年至2018年间在微生物学检查呈阳性的急性椎间盘炎-骨髓炎的所有CT引导下进行的活检。记录了微生物和活检的天数。计算平均值，中位数，偏斜和标准偏差。还计算了每天过去后变为阳性的阳性培养物的比例。结果有96种真正的阳性培养物，男性64位（67％），女性32位（33％），年龄57±18（19-87）。总体而言，包括所有培养结果，阳性培养的平均天数为2.9±3.5天。天数的中位数是2，正偏值为2.9。在第1、2、3、4和5天 分别有48％，68％，78％，85％和89％的活检样本具有阳性微生物培养。结论在CT引导的活检后3天，通过活检样本培养可以鉴定出大约四分之三的盘状炎-骨髓炎病原体。如果计划在阴性微生物培养中进行再次活检，则应考虑这一发现。