Objectives: In the current study, we aimed to investigate the effect of administration of resveratrol (RES) and beta-aminopropionitrile (BAPN) separately and together on the liver fibrosis progression via regulation of the gene expression and protein level of lysyl oxidase (LOX).Materials and methods: The six-week old Wistar rats received carbon tetrachloride (CCl4) intraperitoneally and RES and BAPN were administrated orally for eight weeks. The hepatoprotective effects of RES, BAPN, and combination treatment were evaluated. Then the hepatic protein and gene expression levels of LOX were measured.Results: Both RES and BAPN showed the antifibrotic effect through the reduction of collagen fiber bundles, hepatic hydroxyproline content, and protein level of LOX. The antifibrotic effect increased when RES and BAPN up-taken together.Conclusion: The co-administration of RES and BAPN can be considered as a promising therapeutic approach via targeting LOX.

中文翻译：

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白藜芦醇和β-氨基丙腈的共同给药通过靶向CCl4诱导的大鼠肝纤维化中的赖氨酰氧化酶来减轻肝纤维化的发展。

目的：在本研究中，我们旨在通过调节赖氨酰氧化酶（LOX）的基因表达和蛋白质水平来研究白藜芦醇（RES）和β-氨基丙腈（BAPN）分开或一起给药对肝纤维化进展的影响材料和方法：六周大的Wistar大鼠腹腔接受四氯化碳（CCl4），口服RES和BAPN八周。评估了RES，BAPN和联合治疗对肝脏的保护作用。结果：RES和BAPN均通过减少胶原纤维束，肝羟脯氨酸含量和LOX蛋白水平表现出抗纤维化作用。当RES和BAPN同时摄取时，抗纤维化作用增强。