Apart from their established role in embryonic development, neurotrophins (NTs) have diverse functions in the nervous system. Their role in the integration of physiological and biochemical aspects of the nervous system is currently attracting much attention. Based on a systematic analysis of the literature, we here propose a new paradigm that, by exploiting a novel role of NTs, may help explain the genesis of stress-related psychiatric disorders, opening new avenues for better management of the same. We hypothesize that NTs as an integrated network play a crucial role in maintaining an indivdual's psychological wellbeing. Given the evidence that stress can induce chronic disruption of the hypothalamic-pituitary-adrenal (HPA) axis which, in turn, is causally linked to several psychiatric disorders, this function may be mediated through the homeostatic mechanisms governing regulation of this axis. In fact, NTs, such as nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) are known to participate inneuroendocrine regulation. Recent studies suggest epigenetic modification of NT-HPA axis interplay in the precipitation of psychiatric disorders. Our article highlights why this new knowledge regarding NTs should be considered in the etiogenesis and treatment of stress-induced psychopathology.

中文翻译：

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应激诱导的精神疾病起源中神经营养因子介导的 HPA 轴失调：表观遗传修饰的协调

除了它们在胚胎发育中的既定作用外，神经营养因子 (NT) 在神经系统中具有多种功能。它们在神经系统的生理和生化方面的整合中的作用目前备受关注。基于对文献的系统分析，我们在这里提出了一种新范式，通过利用 NTs 的新作用，可能有助于解释与压力相关的精神疾病的起源，为更好地管理这些疾病开辟新的途径。我们假设 NTs 作为一个综合网络在维持个人的心理健康方面起着至关重要的作用。鉴于有证据表明压力会导致下丘脑 - 垂体 - 肾上腺（HPA）轴的慢性破坏，这反过来又与几种精神疾病有因果关系，这种功能可能是通过调节该轴的稳态机制来调节的。事实上，众所周知，神经生长因子 (NGF) 和脑源性神经营养因子 (BDNF) 等 NTs 参与神经内分泌调节。最近的研究表明 NT-HPA 轴的表观遗传修饰在精神疾病的沉淀中相互作用。我们的文章强调了为什么在压力诱发的精神病理学的病因发生和治疗中应该考虑这种关于 NTs 的新知识。