During my postdoc interview in June of 1998, I asked Günter why he was moving more towards the nucleus in his latest studies. He said, “Well Joe, that’s where everything starts.” By the end of the interview, I accepted the postdoc. He had a way of making everything sound so cool. Günter’s progression was natural, since the endoplasmic reticulum and the nucleus are the only organelles that share the same membrane. The nuclear envelope extends into a double membrane system with nuclear pore complexes embedded in the pore membrane openings. Even while writing this review, I remember Günter stressing; it is the nuclear pore complex. Just saying nuclear pore doesn’t encompass the full magnitude of its significance. The nuclear pore complex is one of the largest collection of proteins that fit together for an overall function: transport. This review will cover the Blobel lab contributions in the quest for the blueprint of the nuclear pore complex from isolation of the nuclear envelope and nuclear lamin to the ring structures.

中文翻译：

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寻找核孔复合体的蓝图。

在1998年6月的博士后采访中，我问昆特（Günter）为什么他在最近的研究中更加朝着原子核方向发展。他说：“好吧，这就是一切的开始。” 面试结束时，我接受了博士后。他有办法使一切听起来都很棒。昆特的进展是自然的，因为内质网和细胞核是共享同一膜的仅有的细胞器。核包膜延伸到双层膜系统中，核孔复合物嵌入孔膜开口中。即使写这篇评论，我也记得昆特在强调。它是核孔复合体。只是说核孔并不涵盖其重要性的全部大小。核孔复合物是蛋白质的最大集合之一，这些蛋白质可以合在一起实现整体功能：转运。