Langerhans cells (LCs) are epidermal immune cells of myeloid origin. Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC-mediated effects including the relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis and promotion of a Th17 response in Candida infection. LCs may have a protective or suppressive function in pathologies of the skin, with differing functions being driven by the skin milieu. Understanding LC function will help guide the development of interventions that modulate these cells for therapeutic benefit.

中文翻译：

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朗格汉斯细胞在皮肤病理中的作用。

朗格汉斯细胞（LC）是髓样来源的表皮免疫细胞。尽管主要认为这些细胞在皮肤中起防御作用，但现在的证据表明，LC介导的作用范围广泛，包括单纯疱疹感染中病毒抗原的传递，特应性皮炎中嗜酸性粒细胞的募集以及Th17应答的促进。念珠菌感染。LC在皮肤病理中可能具有保护或抑制功能，其中不同的功能由皮肤环境驱动。了解LC功能将有助于指导调节这些细胞的治疗手段的开发。