OBJECTIVE To investigate effectiveness of two different high-frequency repetitive transcranial magnetic stimulation (rTMS) protocols on pain, fatigue, quality of life (QoL) and depression in female patients with fibromyalgia. METHODS Thirty patients were randomized into three groups. Fifteen sessions of 10 Hz (90% resting motor threshold-RMT, 1200 pulses) rTMS were applied to left primary motor cortex and left dorsolateral prefrontal cortex (DLPFC) in Group M1 (n:10) and Group DLPFC (n:10), respectively. Group sham (n = 10) received 15 sessions of sham rTMS over 3 weeks. Visual Analogue Scale, Fibromyalgia Impact Questionnaire, Fatigue Severity Scale, Short-form 36, and Beck Depression Inventory were assessed at baseline and at the end of the treatments by a blinded-experienced assessor. RESULTS Significant improvements in pain, QoL, and depression scores were observed in three groups. However, improvements in depression, physical functioning, physical role functioning, and general health perceptions were greater in active rTMS groups than in sham group. Emotional role functioning was only improved in Group M1. The decrease in VAS scores was significantly greater in Group M1 when compared to sham group. Change in physical role functioning was significantly greater in Group DLPFC than in Group M1. CONCLUSIONS Significant improvements in physical role functioning, physical functioning, depression, and general health perceptions were achieved in active rTMS groups. Further clinical studies on larger samples involving both sexes with longer follow-up durations are needed.

中文翻译：

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在纤维肌痛综合征中，高频重复经颅磁刺激左初级运动皮层优于刺激左背外侧前额叶皮层吗？

目的探讨两种不同的高频重复经颅磁刺激（rTMS）方案对女性纤维肌痛患者的疼痛，疲劳，生活质量（QoL）和抑郁的疗效。方法将30例患者随机分为三组。在M1组（n：10）和DLPFC组（n：10）的左主运动皮层和左前外侧前额叶皮层（DLPFC）上应用15次10 Hz（90％静息运动阈值RMT，1200脉冲）rTMS，分别。假组（n = 10）在3周内接受了15次假rTMS。在基线和治疗结束时，由经验丰富的盲人评估视觉模拟量表，纤维肌痛影响问卷，疲劳严重程度量表，简短表格36和贝克抑郁量表。结果疼痛，生活质量，在三组中观察到抑郁和抑郁评分。但是，积极的rTMS组在抑郁，身体机能，身体角色机能和一般健康感方面的改善比假手术组更大。情绪角色功能仅在M1组得到改善。与假手术组相比，M1组的VAS评分下降幅度更大。DLPFC组的身体角色功能变化明显大于M1组。结论在活跃的rTMS组中，身体角色功能，身体功能，抑郁和一般健康感有了显着改善。需要对涉及更长随访时间的性别的更大样本进行进一步的临床研究。积极的rTMS组的身体角色功能和总体健康感知要比假组高。情绪角色功能仅在M1组得到改善。与假手术组相比，M1组的VAS评分下降幅度更大。DLPFC组的身体角色功能变化明显大于M1组。结论在活跃的rTMS组中，身体角色功能，身体功能，抑郁和一般健康感有了显着改善。需要对涉及更长随访时间的性别的更大样本进行进一步的临床研究。积极的rTMS组的身体角色功能和总体健康感知要比假组高。情绪角色功能仅在M1组得到改善。与假手术组相比，M1组的VAS评分下降幅度更大。DLPFC组的身体角色功能变化明显大于M1组。结论在活跃的rTMS组中，身体角色功能，身体功能，抑郁和一般健康感有了显着改善。需要对涉及更长随访时间的性别的更大样本进行进一步的临床研究。与假手术组相比，M1组的VAS评分下降幅度更大。DLPFC组的身体角色功能变化明显大于M1组。结论在活跃的rTMS组中，身体角色功能，身体功能，抑郁和一般健康感得到了显着改善。需要对涉及更长随访时间的性别的更大样本进行进一步的临床研究。与假手术组相比，M1组的VAS评分下降幅度更大。DLPFC组的身体角色功能变化明显大于M1组。结论在活跃的rTMS组中，身体角色功能，身体功能，抑郁和一般健康感得到了显着改善。需要对涉及更长随访时间的性别的更大样本进行进一步的临床研究。