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Dynamic limbic networks and social diversity in vertebrates: From neural context to neuromodulatory patterning
Frontiers in Neuroendocrinology ( IF 6.5 ) Pub Date : 2009-10-01 , DOI: 10.1016/j.yfrne.2009.05.007
James L Goodson 1 , David Kabelik 1
Affiliation  

Vertebrate animals exhibit a spectacular diversity of social behaviors, yet a variety of basic social behavior processes are essential to all species. These include social signaling; discrimination of conspecifics and sexual partners; appetitive and consummatory sexual behaviors; aggression and dominance behaviors; and parental behaviors (the latter with rare exceptions). These behaviors are of fundamental importance and are regulated by an evolutionarily conserved, core social behavior network (SBN) of the limbic forebrain and midbrain. The SBN encodes social information in a highly dynamic, distributed manner, such that behavior is most strongly linked to the pattern of neural activity across the SBN, not the activity of single loci. Thus, shifts in the relative weighting of activity across SBN nodes can conceivably produce almost limitless variation in behavior, including diversity across species (as weighting is modified through evolution), across behavioral contexts (as weights change temporally) and across behavioral phenotypes (as weighting is specified through heritable and developmental processes). Individual neural loci may also express diverse relationships to behavior, depending upon temporal variations in their functional connectivity to other brain regions ("neural context"). We here review the basic properties of the SBN and show how behavioral variation relates to functional connectivity of the network, and discuss ways in which neuroendocrine factors adjust network activity to produce behavioral diversity. In addition to the actions of steroid hormones on SBN state, we examine the temporally plastic and evolutionarily labile properties of the nonapeptides (the vasopressin- and oxytocin-like neuropeptides), and show how variations in nonapeptide signaling within the SBN serve to promote behavioral diversity across social contexts, seasons, phenotypes and species. Although this diversity is daunting in its complexity, the search for common "organizing principles" has become increasingly fruitful. We focus on multiple aspects of behavior, including sexual behavior, aggression and affiliation, and in each of these areas, we show how broadly relevant insights have been obtained through the examination of behavioral diversity in a wide range of vertebrate taxa.

中文翻译:

脊椎动物的动态边缘网络和社会多样性:从神经背景到神经调节模式

脊椎动物表现出惊人的社会行为多样性,但各种基本的社会行为过程对所有物种都是必不可少的。这些包括社交信号;对同种人和性伴侣的歧视;有食欲和完美的性行为;攻击性和支配性行为;和父母的行为(后者很少有例外)。这些行为具有根本的重要性,并由边缘前脑和中脑的进化保守的核心社会行为网络 (SBN) 调节。SBN 以高度动态、分布式的方式对社会信息进行编码,因此行为与整个 SBN 的神经活动模式有最密切的联系,而不是单个位点的活动。因此,可以想象,跨 SBN 节点活动的相对权重的变化可以产生几乎无限的行为变化,包括跨物种(因为权重通过进化修改)、跨行为背景(因为权重随时间变化)和跨行为表型(因为权重被指定)通过遗传和发育过程)。个体神经位点也可能表达与行为的不同关系,这取决于它们与其他大脑区域(“神经上下文”)的功能连接的时间变化。我们在这里回顾了 SBN 的基本特性,并展示了行为变化与网络功能连接性的关系,并讨论了神经内分泌因素调整网络活动以产生行为多样性的方式。除了类固醇激素对 SBN 状态的作用外,我们还检查了九肽(加压素和催产素样神经肽)的时间可塑性和进化不稳定特性,并展示了 SBN 内九肽信号传导的变化如何促进行为多样性跨越社会背景、季节、表型和物种。尽管这种多样性的复杂性令人生畏,但对共同“组织原则”的探索已经变得越来越富有成效。我们关注行为的多个方面,包括性行为、攻击性和从属关系,并且在这些领域中的每一个方面,我们都展示了通过检查各种脊椎动物类群的行为多样性获得的广泛相关见解。我们检查了九肽(血管加压素和催产素样神经肽)的时间可塑性和进化不稳定特性,并展示了 SBN 内九肽信号的变化如何促进跨社会环境、季节、表型和物种的行为多样性。尽管这种多样性的复杂性令人生畏,但对共同“组织原则”的探索已经变得越来越富有成效。我们关注行为的多个方面,包括性行为、攻击性和从属关系,并且在每个领域,我们展示了通过检查各种脊椎动物分类群的行为多样性获得的广泛相关见解。我们研究了九肽(血管加压素和催产素样神经肽)的时间可塑性和进化不稳定特性,并展示了 SBN 内九肽信号的变化如何促进跨社会环境、季节、表型和物种的行为多样性。尽管这种多样性的复杂性令人生畏,但对共同“组织原则”的探索已经变得越来越富有成效。我们关注行为的多个方面,包括性行为、攻击性和从属关系,并且在这些领域中的每一个方面,我们都展示了通过检查各种脊椎动物类群的行为多样性获得的广泛相关见解。并展示 SBN 内九肽信号的变化如何促进跨社会环境、季节、表型和物种的行为多样性。尽管这种多样性的复杂性令人生畏,但对共同“组织原则”的探索已变得越来越富有成效。我们关注行为的多个方面,包括性行为、攻击性和从属关系,并且在这些领域中的每一个方面,我们都展示了通过检查各种脊椎动物类群的行为多样性获得的广泛相关见解。并展示 SBN 内九肽信号的变化如何促进跨社会环境、季节、表型和物种的行为多样性。尽管这种多样性的复杂性令人生畏,但对共同“组织原则”的探索已经变得越来越富有成效。我们关注行为的多个方面,包括性行为、攻击性和从属关系,并且在这些领域中的每一个方面,我们都展示了通过检查各种脊椎动物类群的行为多样性获得的广泛相关见解。
更新日期:2009-10-01
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