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Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α.
Alcohol ( IF 2.5 ) Pub Date : 2019-11-20 , DOI: 10.1016/j.alcohol.2019.11.005
Ansel T Hillmer 1 , Haleh Nadim 2 , Lesley Devine 2 , Peter Jatlow 3 , Stephanie S O'Malley 4
Affiliation  

BACKGROUND Acute alcohol consumption triggers release of cytokines, which are immune signaling molecules. Dysregulated cytokine levels are associated with impaired immune function, and peripheral cytokine levels may communicate with the brain to propagate drinking-related behaviors. This exploratory study aims to characterize the peripheral cytokine response to an alcohol challenge in a well-controlled laboratory setting. METHODS Moderate alcohol drinkers (n = 17), abstinent for >5 days, consumed alcohol calibrated to achieve blood concentrations of 120 mg/dL. Serum cytokine levels (IL-6, IL-8, IL-12, IFN-γ, TNF-α) were measured prior to drinking, 6 h after drinking, and 24 h after drinking. Linear mixed models evaluated within-subject differences in cytokine levels over time. RESULTS The pro-inflammatory chemokine IL-8 significantly increased 6 h after alcohol [F(1,34) = 4.13, p = 0.0002, d' = 0.5]. In contrast, the pro-inflammatory cytokine TNF-α significantly decreased 6 h after alcohol [F(1,34) = -3.07, p = 0.004, d' = 0.3]. No cytokines were significantly different from baseline 24 h after alcohol. CONCLUSIONS In our exploratory data, acute alcohol challenge (120 mg/dL) elicits dynamic changes in the pro-inflammatory molecules IL-8 and TNF-α. The findings help inform the temporal profile of cytokine response to alcohol, and identify IL-8 as a cytokine of interest for future studies of periphery-brain immune communication.

中文翻译:

急性饮酒会改变外周细胞因子 IL-8 和 TNF-α。

背景技术急性饮酒会触发细胞因子的释放,细胞因子是免疫信号分子。细胞因子水平失调与免疫功能受损有关,外周细胞因子水平可能与大脑交流以传播与饮酒相关的行为。这项探索性研究旨在在控制良好的实验室环境中表征外周细胞因子对酒精挑战的反应。方法 中度饮酒者(n = 17),戒酒超过 5 天,消耗的酒精经过校准以达到 120 mg/dL 的血液浓度。在饮酒前、饮酒后 6 小时和饮酒后 24 小时测量血清细胞因子水平(IL-6、IL-8、IL-12、IFN-γ、TNF-α)。线性混合模型评估了受试者内细胞因子水平随时间的差异。结果 酒精后 6 小时促炎趋化因子 IL-8 显着增加 [F(1,34) = 4.13, p = 0.0002, d' = 0.5]。相比之下,促炎细胞因子 TNF-α 在酒精后 6 小时显着降低 [F(1,34) = -3.07, p = 0.004, d' = 0.3]。酒精后 24 小时没有细胞因子与基线显着不同。结论 在我们的探索性数据中,急性酒精刺激 (120 mg/dL) 引起促炎分子 IL-8 和 TNF-α 的动态变化。这些发现有助于了解细胞因子对酒精的反应的时间分布,并将 IL-8 确定为未来外周脑免疫通讯研究的一种感兴趣的细胞因子。d' = 0.3]。酒精后 24 小时没有细胞因子与基线显着不同。结论 在我们的探索性数据中,急性酒精刺激 (120 mg/dL) 引起促炎分子 IL-8 和 TNF-α 的动态变化。这些发现有助于了解细胞因子对酒精的反应的时间分布,并将 IL-8 确定为未来外周脑免疫通讯研究的一种感兴趣的细胞因子。d' = 0.3]。酒精后 24 小时没有细胞因子与基线显着不同。结论 在我们的探索性数据中,急性酒精刺激 (120 mg/dL) 引起促炎分子 IL-8 和 TNF-α 的动态变化。这些发现有助于了解细胞因子对酒精的反应的时间分布,并将 IL-8 确定为未来外周脑免疫通讯研究的一种感兴趣的细胞因子。
更新日期:2020-04-20
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