Chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) have been shown to cause monocyte and natural killer cell chemotaxis and polymorphonuclear cell chemotaxis, respectively. Additionally, MCP-1 signalling has been implicated in modulating pain. Elevated synovial fluid concentrations of MCP-1 and IL-8 have been demonstrated in humans with osteoarthritis, but currently there are no studies evaluating synovial MCP-1 or IL-8 concentrations in dogs. Additionally, there are no canine studies evaluating the correlation between these chemokines and caregiver perceived pain and mobility, as measured by the clinical metrology instrument, Liverpool Osteoarthritis in Dogs. This study documented elevated synovial fluid concentrations of IL-8 and MCP-1 in the stifle of dogs with secondary osteoarthritis compared with normal stifles. However, this study found no correlation between MCP-1 or IL-8 and Liverpool Osteoarthritis in Dogs or radiographic severity of osteoarthritis.

中文翻译：

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窒息性骨关节炎狗中单核细胞趋化蛋白-1和白细胞介素8的滑液浓度升高。

趋化因子，例如单核细胞趋化蛋白-1（MCP-1）和白介素8（IL-8）已显示分别引起单核细胞和自然杀伤细胞趋化性以及多形核细胞趋化性。此外，MCP-1信号传导与调节疼痛有关。已经在患有骨关节炎的人中证明了滑膜液中MCP-1和IL-8的浓度升高，但是目前尚无评估狗滑膜MCP-1或IL-8浓度的研究。此外，还没有犬类研究评估这些趋化因子与护理者感觉到的疼痛和活动性之间的相关性，这是通过临床计量仪器“利物浦狗骨关节炎”测量的。这项研究表明，继发性骨关节炎狗的膝关节中滑液中IL-8和MCP-1的浓度较正常人高。但是，这项研究发现，MCP-1或IL-8与利物浦犬骨关节炎或骨关节炎的放射学严重程度之间无相关性。