Numerous methods for estimating heritability have been proposed; however, unlike quantitative phenotypes, heritability estimation for dichotomous phenotypes is computationally and statistically complex, and the use of heritability is infrequent. In this study, we developed a statistical method to estimate heritability of dichotomous phenotypes using a liability threshold model in the context of ascertained family-based samples. This model assumes that dichotomous phenotypes are determined by unobserved latent variables that are normally distributed and can be applied to general pedigree data. The proposed methods were applied to simulated data and Korean type-2 diabetes family-based samples, and the accuracy of the estimates provided by the experimental methods was compared with that of the established methods.

中文翻译：

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在确定的基于家庭的样本上使用责任阈值模型对二分型表型的遗传力估计。

已经提出了许多估计遗传力的方法。但是，与定量表型不同，二分型表型的遗传力估算在计算和统计上都很复杂，并且遗传力的使用很少。在这项研究中，我们开发了一种统计方法，用于在确定的基于家庭的样本的背景下，使用责任阈值模型来估计二分型表型的遗传力。该模型假定二分表型是由未观察到的潜变量确定的，这些潜变量呈正态分布并且可以应用于一般的谱系数据。将该方法应用于模拟数据和基于韩国2型糖尿病家庭的样本，并将实验方法提供的估计值与已建立的方法进行了比较。