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The potentials of umbilical cord-derived mesenchymal stem cells in the treatment of multiple sclerosis
Reviews in the Neurosciences ( IF 3.4 ) Pub Date : 2019-04-26 , DOI: 10.1515/revneuro-2018-0057
Ahmad Mehdipour 1 , Ayyub Ebrahimi 2 , Mohammad-Reza Shiri-Shahsavar 3 , Jafar Soleimani-Rad 4 , Leila Roshangar 4, 5 , Mohammad Samiei 6 , Abbas Ebrahimi-Kalan 7, 8
Affiliation  

Stem cell therapy has indicated a promising treatment capacity for tissue regeneration. Multiple sclerosis is an autoimmune-based chronic disease, in which the myelin sheath of the central nervous system is destructed. Scientists have not discovered any cure for multiple sclerosis, and most of the treatments are rather palliative. The pursuit of a versatile treatment option, therefore, seems essential. The immunoregulatory and non-chronic rejection characteristics of mesenchymal stem cells, as well as their homing properties, recommend them as a prospective treatment option for multiple sclerosis. Different sources of mesenchymal stem cells have distinct characteristics and functional properties; in this regard, choosing the most suitable cell therapy approach seems to be challenging. In this review, we will discuss umbilical cord/blood-derived mesenchymal stem cells, their identified exclusive properties compared to another adult mesenchymal stem cells, and the expectations of their potential roles in the treatment of multiple sclerosis.

中文翻译:

脐带间充质干细胞治疗多发性硬化的潜力

干细胞疗法已显示出对组织再生的有希望的治疗能力。多发性硬化症是一种基于自身免疫的慢性疾病,其中中枢神经系统的髓鞘被破坏。科学家们还没有发现任何治疗多发性硬化症的方法,而且大多数治疗方法都是姑息性的。因此,追求多功能治疗方案似乎至关重要。间充质干细胞的免疫调节和非慢性排斥特征,以及它们的归巢特性,推荐它们作为多发性硬化症的前瞻性治疗选择。不同来源的间充质干细胞具有不同的特征和功能特性;在这方面,选择最合适的细胞治疗方法似乎具有挑战性。在本次审查中,
更新日期:2019-04-26
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