Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels.,Histology and Histopathology

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Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels.
Histology and Histopathology ( IF 2 ) Pub Date : 2018-10-10 , DOI: 10.14670/hh-18-051
Rong Yin _{1,

2,

3} , Shawn J Rice ₄ , Jinwei Wang _{1,

5} , Lin Gao ₆ , Joseph Tsai ₁ , Radean T Anvari ₁ , Fang Zhou _{1,

5} , Xin Liu ₄ , Gang Wang ₆ , Yuxin Tang ₅ , Martin C Mihm ₇ , Chandra P Belani _{4,

8} , Dong-Bao Chen ₉ , J Stuart Nelson _{1,

10} , Wenbin Tan _{1,

2}

Affiliation

Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA.
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Department of Dermatology, the Second Hospital of Shanxi Medical University, Taiyuan, China.
Penn State Cancer Institute, Hershey, PA, USA.
Department of Urology, the Xiangya 3rd Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Dermatology, Xijing Hospital, Xi'an, China.
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Department of Medicine, Penn State College of Medicine, Hershey, PA, USA.
Department of Obstetrics and Gynecology, University of California, Irvine, California, USA.
Department of Biomedical Engineering, University of California, Irvine, California, USA.

Port wine stain (PWS) is characterized as a progressive dilatation of immature venule-like vasculatures which result from differentiation-impaired endothelial cells. In this study, we aimed to identify the major biological pathways accounting for the pathogenesis of PWS.

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