Objectives: To determine 1) the sensitivity of contrast-enhanced CT (CECT) for detection of primary canine insulinomas and metastases 2) the sensitivity of CECT to locate canine insulinomas within the pancreas and 3) the CECT attenuation pattern of canine insulinomas and post-contrast phase in which insulinomas have the best visibility.

Methods: A retrospective review was performed of the medical records of 27 canine insulinoma patients. Simultaneous occurrence of blood glucose < 3.5 mmol/L (reference interval: 4.2–5.8 mmol/L) and plasma insulin > 10 mIU/L (reference interval: 1.4–24.5 mIU/L) were considered diagnostic for insulinoma. The dogs had a mean age of 9.0 ± 1.7 (SD) years and comprised 11 males and 17 females.

Results: Using CECT-scans, 26/27 insulinomas were successfully detected. However, CECT-scans predicted the correct location of insulinomas within the pancreas in only 14/27 dogs. In 9/13 inaccurately located insulinoma cases, the location error was major. There was no significant difference between triple, double and single-phase CECT-scans with location accuracies of 54%, 50% and 50%, respectively. Also, there was no specific post-contrast phase in which insulinomas could be visualised best. Detection of lymph node metastases with CECT-scans had a sensitivity of 67% (10/15 lymph node metastases). Detection of liver metastases had a sensitivity of 75% (6/8 liver metastases). This study highlights that major location errors mainly occurred if single- or double-phase CECT-scans were used (6/9 cases).

Conclusion: It is suggested that triple-phase CECT-scans have superior outcome over single- or double-phase CECT-scans in pre-operative imaging of canine insulinomas.

目的：确定1）对比增强CT（CECT）检测原发性犬胰岛素瘤和转移灶的敏感性2）CECT在胰腺内定位犬胰岛素瘤的敏感性，以及3）犬胰岛素瘤和肝癌术后CECT衰减模式胰岛素瘤具有最佳可见性的对比阶段。

方法：回顾性分析27例犬胰岛素瘤患者的病历。血糖<3.5 mmol / L（参考区间：4.2-5.8 mmol / L）和血浆胰岛素> 10 mIU / L（参考区间：1.4-24.5 mIU / L）的同时发生被认为可诊断胰岛素瘤。这些狗的平均年龄为9.0±1.7（SD）岁，由11只雄性和17只雌性组成。

结果：使用CECT扫描成功检测到26/27个胰岛素瘤。然而，CECT扫描仅在14/27只狗中预测了胰岛素瘤在胰腺内的正确位置。在9/13个位置不正确的胰岛素瘤病例中，定位误差较大。三相，双相和单相CECT扫描之间的位置准确度分别为54％，50％和50％没有显着差异。同样，没有特定的造影剂后阶段，胰岛素瘤可以最佳地显示出来。用CECT扫描检测淋巴结转移的敏感性为67％（10/15淋巴结转移）。肝转移的检测灵敏度为75％（6/8肝转移）。这项研究强调指出，如果使用单相或双相CECT扫描，则主要发生位置错误（6/9例）。

结论：建议在犬胰岛素瘤的术前成像中，三相CECT扫描优于单相或双相CECT扫描。