Background

There has been an extensive range of incidence and mortality of breast cancer (BC), and the comprehensively available treatments for BC have not been completely successful in achieving satisfactory outcomes up to date.

Hypothesis

Recently, we are watching intense attention paid to the utilization of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a dietary flavonol in a large group of commonly consumed foods, is widely illustrated to apply inhibitory effects on cancer progression through several mechanisms including apoptosis enhancement, cell cycle arrest, metastasis and angiogenesis inhibition, antioxidant replication and estrogen receptor modulation.

Methods

We reviewed the most relevant papers published from 2009 to 2018 (except 15 articles), using “pub med” and “web of science” and the search terms “Quercetin”; “Breast cancer”; “Flavonoid”; “Apoptosis”; “Cell cycle”; “chemotherapy”; “Drug resistance”; “Metastasis; “Oxidative stress”, “Breast cancer receptors” and “Quercetin derivatives”. We selected studies on the association of quercetin with breast cancer in different dimensions.

Results

Despite the remarkable number of studies on quercetin’s efficacy, multiple aspects of this herbal compound have not been clarified well and this review provides a summarized update of the recent evidence on biologically available efficacies of quercetin which would establish a further biological basis for the potential therapeutic acquisition of quercetin as an anticancer drug.

Conclusion

Basic, epidemiological and genetic studies point to the potential role of quercetin in the treatment of breast cancer, but randomized and controlled trials are of great importance to establish the clinical efficacy of quercetin in ill or at-risk subjects.

中文翻译：

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槲皮素在不同维度上对人乳腺癌的治疗潜力。

背景

乳腺癌（BC）的发病率和死亡率范围广泛，并且迄今为止，针对BC的全面可用的治疗方法尚未完全成功地获得令人满意的结果。

假设

最近，我们正在密切关注天然化合物作为一种新型的癌症治疗策略的利用。槲皮素是一大类常见食用食品中的饮食类黄酮醇，其通过多种机制（包括凋亡增强，细胞周期阻滞，转移和血管生成抑制，抗氧化剂复制和雌激素受体调节）对癌症进展施加抑制作用。

方法

我们使用“ pub med”和“ science of web”以及搜索词“ Quercetin”审查了2009年至2018年发表的最相关论文（15篇文章除外）；“乳腺癌”; “类黄酮”；“凋亡”；“细胞周期”; “化学疗法”；“耐药性”; “转移; “氧化应激”，“乳腺癌受体”和“槲皮素衍生物”。我们选择了槲皮素与乳腺癌在不同维度上的关联的研究。

结果

尽管对槲皮素的功效进行了大量研究，但该草药化合物的多个方面仍未得到很好的阐明，该综述提供了有关槲皮素生物学上有效功效的最新证据的摘要更新，这将为潜在的治疗性收购奠定进一步的生物学基础。槲皮素作为抗癌药物。

结论

基础，流行病学和遗传学研究表明槲皮素在乳腺癌的治疗中具有潜在的作用，但是随机和对照试验对于确定槲皮素在生病或高危受试者中的临床疗效至关重要。