BACKGROUND Pregnancy is a period presenting with many physiological adaptation mechanisms. One of the structures in which these mechanisms are observed is ocular tissues. The cornea, lacrimal and meibomian glands, and chorioretinal complex are all among the structures affected by changes during pregnancy. In this study we aimed to evaluate the macular and optic disc vessel density (VD) changes by Optical Coherence Tomography Angiography (OCTA) imaging in pregnancy. METHODS A total of 248 eyes from 124 pregnant women and 80 eyes from 40 healthy control women were involved. Vessel densities of macula were evaluated for superficial capillary plexus (SCP) and deep capillary plexus (DCP) in whole macula, foveal, parafoveal and perifoveal region. Peripapillary and whole optic disc VDs were also evaluated. Vessel densities of macula and optic disc were compared between control individuals and pregnant women. Vessel densities in different trimesters were also evaluated. RESULTS Modest but significant differences in VDs of whole macula of SCP and DCP were observed in pregnancy group. Additionally, perifoveal and parafoveal region of SCP, whole disc and radial peripapillary capillary VD were significantly higher in pregnancy group. There was no correlation between VD ratios of macula and optic disc and pregnancy weeks and trimesters. CONCLUSIONS This is the first study focusing on the OCTA parameters in pregnant individuals. These findings suggest that physiological changes during pregnancy are not limited to the cornea, eyelids and the choroid but also to the retinal and optic disc vasculature.

中文翻译：

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怀孕期间眼血管的变化：光学相干断层扫描血管造影研究。

背景技术怀孕是呈现出许多生理适应机制的时期。观察到这些机制的结构之一是眼组织。角膜，泪腺和睑板腺以及脉络膜视网膜复合物都是受孕期变化影响的结构。在这项研究中，我们旨在通过妊娠期光学相干断层扫描血管造影（OCTA）成像评估黄斑和视盘血管密度（VD）的变化。方法纳入了124例孕妇的248眼和40例健康对照妇女的80眼。对黄斑的血管密度进行评估，以评估整个黄斑，中央凹，中央凹和中央凹区域的浅表毛细血管丛（SCP）和深毛细血管丛（DCP）。还评估了乳头周围和整个视盘的VD。比较了对照组和孕妇的黄斑和视盘的血管密度。还评估了不同妊娠期的血管密度。结果在妊娠组中，SCP和DCP的整个黄斑区的VD有适度但显着的差异。此外，妊娠组的SCP的小凹和小凹旁区域，整个椎间盘和放射状乳头状毛细血管VD明显升高。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。还评估了不同妊娠期的血管密度。结果在妊娠组中，SCP和DCP的整个黄斑区的VD有适度但显着的差异。此外，妊娠组的SCP的小凹和小凹旁区域，整个椎间盘和放射状乳头状毛细血管VD明显升高。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。还评估了不同妊娠期的血管密度。结果在妊娠组中，SCP和DCP的整个黄斑区的VD有适度但显着的差异。此外，妊娠组的SCP的小凹和小凹旁区域，整个椎间盘和放射状乳头状毛细血管VD明显升高。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。结果在妊娠组中，SCP和DCP的整个黄斑区的VD有适度但显着的差异。此外，妊娠组的SCP的小凹和小凹旁区域，整个椎间盘和放射状乳头状毛细血管VD明显升高。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。结果在妊娠组中，SCP和DCP的整个黄斑区的VD有适度但显着的差异。此外，妊娠组的SCP的小凹和小凹旁区域，整个椎间盘和放射状乳头状毛细血管VD明显升高。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。黄斑和视盘的VD比与妊娠周和妊娠期之间没有相关性。结论这是第一项针对孕妇的OCTA参数的研究。这些发现表明，怀孕期间的生理变化不仅限于角膜，眼睑和脉络膜，还不仅限于视网膜和视盘血管。