Real-time, large-scale simulation of biological systems is challenging due to different types of nonlinear functions describing biochemical reactions in the cells. The promise of the high speed, cost effectiveness, and power efficiency in addition to parallel processing has made application-specific hardware an attractive simulation platform. This paper proposes high-speed and low-cost digital hardware to emulate a biological-plausible astrocyte and glutamate-release mechanism. The nonlinear terms of these models were calculated using a high-precision and cost-effective algorithm. Subsequently, the modified models were simulated to study and validate their functions. We developed several hardware versions by setting different constraints to investigate trade-offs and find the best possible design. FPGA implementation results confirmed the ability of the design to emulate biological cell behaviours in detail with high accuracy. As for performance, the proposed design turned out to be faster and more efficient than previously published works that targeted digital hardware for biological-plausible astrocytes.

中文翻译：

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CORDIC-星形胶质细胞：FPGA上的三价谷氨酸盐-IP3-Ca2 +相互作用动力学

由于描述细胞中生化反应的非线性函数类型不同，因此实时，大规模地模拟生物系统具有挑战性。除了并行处理外，高速，低成本，高能效的承诺使专用硬件成为有吸引力的仿真平台。本文提出了一种高速，低成本的数字硬件，以模拟生物似的星形胶质细胞和谷氨酸释放机制。这些模型的非线性项是使用高精度且具有成本效益的算法计算的。随后，对修改后的模型进行仿真以研究和验证其功能。我们通过设置不同的约束条件来开发多种硬件版本，以权衡取舍并找到最佳的设计。FPGA的实施结果证实了该设计具有高度精确地模拟生物细胞行为的能力。在性能方面，与以前发布的针对生物似的星形胶质细胞的数字硬件的作品相比，拟议的设计变得更快，更高效。