Background Use of psychoactive substances is a common finding in studies on first-episode psychosis (FEP), and this has prognostic implications. We know very little about psychoactive substance use (SU) among patients with FEP in the Eastern Cape province (EC) of South Africa (SA). Aim The study seeks to determine SU prevalence and associated features among inpatients with non-affective FEP in an acute mental health unit (MHU) in Nelson Mandela Bay, EC. Setting Researchers conducted a retrospective clinical file review of a 12-month admission cohort of patients with FEP, without a concurrent mood episode, to the Dora Nginza Hospital MHU. Information collected included SU history, psychiatric diagnoses, and demographics. Data were then subjected to statistical analysis. Methods Researchers conducted a retrospective clinical file review of a 12-month admission cohort of patients with FEP, without a concurrent mood episode, to the Dora Nginza Hospital MHU. Information collected included SU history, psychiatric diagnoses and demographics. Data were then subjected to statistical analysis. Results A total of 117 patients (86 [73.5%] males; 31 [26.5%] females) aged 18–60 years (mean 29 years) met the inclusion criteria. After controlling for missing information, 95 of 117 (81.2%) patients had a history of active or previous SU, 82 of 90 (91.1%) were single and 61 of 92 (66.3%) were unemployed. A significant association was found between SU and unemployment (p < 0.001), as well as male sex (p < 0.001). The most common substances used were cannabis (59.8%), followed by alcohol (57.3%) and stimulants (46.4%). Conclusion In keeping with national and international literature, the results of this study showed a high prevalence of substance use in South African patients with first-episode psychosis. The high prevalence of lifetime substance use in this cohort compared to previous studies in South Africa requires further investigation and highlights the urgent need for dual diagnosis services in the Eastern Cape province.

中文翻译：

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纳尔逊曼德拉湾的首发精神病和物质使用：急性心理健康部门的调查结果。

背景 精神活性物质的使用是首发精神病 (FEP) 研究中的常见发现，这具有预后意义。我们对南非 (SA) 东开普省 (EC) 的 FEP 患者的精神活性物质使用 (SU) 知之甚少。目的 本研究旨在确定欧共体纳尔逊曼德拉湾急性精神健康病房 (MHU) 中非情感性 FEP 住院患者的 SU 患病率和相关特征。设置 研究人员对 Dora Nginza 医院 MHU 的 12 个月 FEP 患者入院队列进行了回顾性临床文件审查，没有同时出现情绪发作。收集的信息包括 SU 病史、精神病诊断和人口统计。然后对数据进行统计分析。方法 研究人员对 Dora Nginza 医院 MHU 的 12 个月 FEP 患者入院队列进行回顾性临床文件审查，没有同时出现情绪发作。收集的信息包括 SU 病史、精神病诊断和人口统计。然后对数据进行统计分析。结果共有117名患者（86名[73.5%]男性；31名[26.5%]女性）年龄在18-60岁（平均29岁）符合纳入标准。在控制缺失信息后，117 名患者中有 95 名（81.2%）有活动或既往 SU 病史，90 名患者中有 82 名（91.1%）为单身，92 名中有 61 名（66.3%）失业。SU 与失业（p < 0.001）以及男性（p < 0.001）之间存在显着关联。最常用的物质是大麻（59.8%），其次是酒精（57.3%）和兴奋剂（46.4%）。结论 与国内和国际文献一致，本研究结果显示南非首发精神病患者的物质使用率很高。与之前在南非的研究相比，该队列中终生物质使用的高流行率需要进一步调查，并强调了东开普省对双重诊断服务的迫切需求。