Abstract

Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer, corilagiffithiin (1) and one new galloyl-glucoside (2), alongside six known ones (3–8). Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values. Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated l-cysteine adduct. At a concentration of 50 μM, compounds 1–3 showed no anti-inflammatory activities.

Graphic Abstract

中文翻译：

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大戟茎中的两种新酚类成分。

摘要

上的MeOH提取物的植物化学研究的茎的圆苞大戟导致一个新的可水解鞣质二聚体的隔离，corilagiffithiin（1）和一个新的没食子酰基葡糖苷（2），沿着6级公知的（3 - 8）。它们的结构和绝对构型是通过深度光谱分析并将其1D NMR和MS数据与文献报道的值进行比较来确定的。糖部分的构型是通过酸水解和随后对其相应的三甲基甲硅烷基化的1-半胱氨酸加合物的GC分析来确定的。在50μM的浓度，化合物1 - 3显示没有抗炎活性。

图形摘要