Morphological and immunohistochemical examination was made on 24 gum biopsies obtained from 35- to 60-year-old patients with diagnosis of partial secondary adentia, chronic generalized moderate to severe periodontitis (19 patients), as well as on the biopsy samples from five patients without pathological periodontal changes who underwent dental implantation. Serial paraffin sections were treated with antibodies against Ki-67, VEGF, and SMA. In patients with severe chronic periodontitis, a high proliferative activity of epithelium indicative of hyperplastic changes was observed, as well as a reduced number of the SMA-positive cells and actual absence of the SMA-positive cell couplings associated with the "growth zones" in tissues, which testifies indirectly to a lower tissue regenerative capacity. Hence, before dental implantation, additional anti-inflammatory and pro-regenerative treatment is required.

中文翻译：

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牙周组织的免疫组织化学和形态学研究预测慢性牙周炎患者的牙齿植入结果。

对35到60岁诊断为部分继发性牙本质病，慢性全身中度至重度牙周炎（19例）的24例牙龈活检进行形态学和免疫组化检查，并对5例未进行诊断的患者进行活检进行牙种植的病理性牙周变化。用抗Ki-67，VEGF和SMA的抗体处理连续石蜡切片。在患有严重慢性牙周炎的患者中，观察到上皮的高增生活性表明增生性改变，SMA阳性细胞数量减少，并且实际上不存在与“生长区”相关的SMA阳性细胞偶联。组织，间接证明较低的组织再生能力。因此，在种植牙齿之前，