Osler and colleagues published a cohort study investigating antidepressant medication and suicidal behaviour and violent crime in patients and conscripts (1). They report an increased incidence rate for both events before and after treatment initiation when compared to the follow-up period. They conclude that there is likely no causal effect of antidepressants on either of the two endpoints, because the rates between treated and untreated individuals did not differ substantially at each time-point and the rates of both events did not increase in the antidepressant group after treatment initiation as compared to the pre-treatment time period.

中文翻译：

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对 Osler 等人的评论：对前后差异的误解使作者的结论无效

Osler 及其同事发表了一项队列研究，调查患者和应征者的抗抑郁药物和自杀行为以及暴力犯罪 (1)。他们报告说，与随访期相比，治疗开始前后的事件发生率都有所增加。他们得出结论，抗抑郁药对两个终点中的任何一个都可能没有因果影响，因为在每个时间点，接受治疗和未接受治疗的个体之间的发生率没有显着差异，并且在治疗后抗抑郁药组中这两种事件的发生率没有增加与预处理时间段相比开始。