Background

Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulatum, naturally found in nitrogen-rich soil, whose main transmission route is the inhalation of conidia. Up to 95% of histoplasmosis cases are asymptomatic or transient, and the remaining 5% of cases have pathological manifestations in the lungs, bone marrow, liver, spleen, intestine, mucous membranes, and rarely on the skin. This mycosis has been reported from many endemic areas, mainly in immunosuppressed patients, such as HIV-positive patients, and its disseminated form is rarely reported.

Case report

Histoplama capsulatum was isolated and identified by means of microscopy, culture characteristics and nested PCR from the cutaneous lesions of a non-HIV patient from Vietnam. The patient improved significantly with systemic itraconazole treatment.

Conclusions

Disseminated histoplasmosis with cutaneous involvement in non-HIV patients is an extremely unusual presentation.

中文翻译：

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来自越南的一名非HIV患者的播散性组织胞浆病的异常表现。

背景

组织胞浆菌病是由双形真菌荚膜组织胞浆菌引起的系统性感染，该组织囊菌天然存在于富氮土壤中，其主要传播途径是吸入分生孢子。高达95％的组织胞浆菌病病例是无症状或短暂的，其余5％的病例在肺，骨髓，肝，脾，肠，粘膜中有病理表现，很少在皮肤上。已经从许多流行地区报告了这种真菌病，主要在免疫抑制的患者（如HIV阳性患者）中报道，很少报道其传播形式。

案例报告

从越南的一名非艾滋病毒患者的皮肤病变中，通过显微镜检查，培养特征和巢式PCR分离并鉴定了荚膜组织胞。全身伊曲康唑治疗可使患者明显改善。

结论

非HIV患者中皮肤受累传播的组织胞浆菌病是一种非常不寻常的表现。