PURPOSE Arterial embolization has been shown to be effective and safe for the management of bleeding, especially for postpartum and pelvic traumatic bleeding. We propose to evaluate the proof of concept of feasibility and effectiveness of arterial embolization with absorbable and non-absorbable sutures in a porcine model. MATERIALS AND METHODS In the acute setting (n = 1), several different arteries (mesenteric, splenic, pharyngeal, kidney) were embolized using non-absorbable sutures (NAS): Mersutures™ braided sutures (polyethylene terephthalate). In the chronic setting (n = 3), only lower pole renal arteries were embolized. On the right side, NAS was used, whereas on the left side embolization was realized with absorbable suture (AS): Vicryl® braided suture (polyglactin 910). The chronic group was followed for 3 months. The pigs received contrast-enhanced CT the day before embolization (D-1), after the embolization (D0), at 1 month and 3 months after embolization (M1 and M3); digital subtraction angiography (DSA) was done at D0 and M3 and histological analysis at M3. RESULTS All vascular targets were effectively embolized without any pre- or postoperative complications. Both DSAs and CTs at M3 showed a 100% recanalization rate for the AS embolization and a partial reversal rate for the NAS embolization. A renal hypotrophy in the embolized region was observed during both the M1 and M3 scans for both sutures (AS and NAS) with a clear hypotrophy for the NAS embolized kidney. CONCLUSION Embolization by AS and NAS (FAIR-Embo) is a feasible and effective treatment which opens up the possibility of global use of this inexpensive and widely available embolization agent.

中文翻译：

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永久性和可吸收缝合线在体内进行动脉栓塞的可行性：公平的概念。

目的动脉栓塞术已被证明对出血的治疗是有效和安全的，特别是对于产后和盆腔创伤性出血。我们建议用猪模型中的可吸收和不可吸收缝合线评估动脉栓塞的可行性和有效性的概念证明。材料和方法在急性环境（n = 1）中，使用不可吸收的缝合线（NAS）栓塞数个不同的动脉（肠系膜，脾，咽，肾）：Mersutures™编织缝合线（聚对苯二甲酸乙二酯）。在慢性病（n = 3）中，只有下极肾动脉被栓塞。在右侧使用NAS，而在左侧使用可吸收缝合线（AS）进行栓塞：编织缝合线（Polyglactin 910）。慢性组随访3个月。在栓塞前一天（D-1），栓塞后（D0），栓塞后1个月和3个月（M1和M3），对猪进行对比增强CT检查。在D0和M3进行数字减影血管造影（DSA），在M3进行组织学分析。结果所有血管靶标均被有效栓塞，无术前或术后并发症。M3的DSA和CT均显示AS栓塞的再通率为100％，NAS栓塞的部分逆转率为。在两个缝线（AS和NAS）的M1和M3扫描中均观察到栓塞区域的肾脏萎缩，NAS栓塞的肾脏明显萎缩。