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Cell type-specific structural plasticity of the ciliary transition zone in C. elegans
Biology of the Cell ( IF 2.4 ) Pub Date : 2019-02-14 , DOI: 10.1111/boc.201800042
Jyothi S Akella 1 , Malan Silva 1, 2 , Natalia S Morsci , Ken C Nguyen 3 , William J Rice 4 , David H Hall 3 , Maureen M Barr 1
Affiliation  

The current consensus on cilia development posits that the ciliary transition zone (TZ) is formed via extension of nine centrosomal microtubules. In this model, TZ structure remains unchanged in microtubule number throughout the cilium life cycle. This model does not however explain structural variations of TZ structure seen in nature and could also lend itself to the misinterpretation that deviations from nine‐doublet microtubule ultrastructure represent an abnormal phenotype. Thus, a better understanding of events that occur at the TZ in vivo during metazoan development is required.

中文翻译:

秀丽隐杆线虫纤毛过渡区的细胞类型特异性结构可塑性

目前关于纤毛发育的共识认为纤毛过渡区 (TZ) 是通过九个中心体微管的延伸形成的。在这个模型中,TZ 结构在整个纤毛生命周期中的微管数量保持不变。然而,该模型并不能解释自然界中观察到的 TZ 结构的结构变化,也可能导致误解,即偏离九重微管超微结构代表异常表型。因此,需要更好地了解在后生动物发育过程中在体内 TZ 发生的事件。
更新日期:2019-02-14
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