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The molecular basis for flexibility in the flexible filamentous plant viruses.
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2015-07-15 , DOI: 10.1038/nsmb.3054
Frank DiMaio , Chun-Chieh Chen , Xiong Yu , Brandon Frenz , Yau-Heiu Hsu , Na-Sheng Lin , Edward H Egelman

Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility. We have used cryo-EM to generate an atomic model for bamboo mosaic virus, which reveals flexible N- and C-terminal extensions that allow deformation while still maintaining structural integrity.

中文翻译:

柔韧性丝状植物病毒柔韧性的分子基础。

柔性丝状植物病毒在世界范围内造成病毒性作物损害的一半以上,但也可能对生物技术有用。结构研究始于75年前,但由于病毒体的极端灵活性而失败了。我们已使用cryo-EM生成竹花叶病毒的原子模型,该模型揭示了灵活的N和C端延伸,这些延伸允许变形,同时仍保持结构完整性。
更新日期:2019-11-01
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