Background: Lymphedema includes primary lymphedema (P-LE) and secondary lymphedema (S-LE), which is a chronic progressive disease. The former group is further classified as congenital and acquired P-LE (AP-LE); its etiology is unclear, and only a few studies on its pathophysiology exist. We hypothesized that an autoimmune disease or self-inflammatory mechanism occurs in lymphatic vessels, leading to obstruction.

中文翻译：

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初步报告：肿瘤坏死因子-α 在获得性原发性淋巴水肿中的相关性-组织病理学调查。

背景：淋巴水肿包括原发性淋巴水肿（P-LE）和继发性淋巴水肿（S-LE），后者是一种慢性进行性疾病。前一组进一步分为先天性和后天性 P-LE（AP-LE）；其病因尚不明确，对其病理生理学的研究较少。我们假设淋巴管中发生自身免疫性疾病或自身炎症机制，导致阻塞。