Helicobacter pylori and non-H. pylori Helicobacter (NHPH) are associated with gastritis, ulcer, and gastric neoplasia. Because of the impossibility to culture them, diagnosis remains based on microscopic examination and molecular analysis of biopsies. Owing to the lack of data concerning antibiotic resistance of NHPH, infected patients are usually treated using antibiotics, including clarithromycin. Herein, we describe, for the first time a human infection by Helicobacter suis harboring a mutation associated to clarithromycin resistance in H. pylori. Eradication was successful with a metronidazole-based treatment. This observation highlights the benefit to use genotypic detection of resistance to improve therapeutic management of NHPH infections.

中文翻译：

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首次在猪幽门螺杆菌中检测到对幽门螺杆菌克拉霉素具有抗性的突变：病例报告和文献综述。

幽门螺杆菌和非幽门螺杆菌（NHPH）与胃炎，溃疡和胃肿瘤相关。由于无法进行培养，因此仍需根据显微镜检查和活检分子分析进行诊断。由于缺乏有关NHPH耐药性的数据，通常使用包括克拉霉素在内的抗生素治疗感染的患者。在这里，我们描述，首次人感染幽门螺杆菌猪窝藏在相关联的克拉霉素抗性的突变幽门螺杆菌。用甲硝唑为基础的治疗成功根除。该观察结果突出了使用抗性的基因型检测来改善NHPH感染的治疗管理的益处。